Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.
Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.
Hum Cell. 2022 Jan;35(1):238-249. doi: 10.1007/s13577-021-00645-6. Epub 2021 Nov 17.
Ferroptosis, as an new form of non-apoptotic regulated cell death, plays an important role in human cancers. Although it is reported that HSP27 is an novel regulator of ferroptosis in cancer, it remains unknown how HSP27 affects ferroptosis in glioma. In this study, we examined the effect of HSP27 on the ferroptosis of glioblasotma. HSP27 overexpression protects glioblastoma cells from erastin-induced ferroptosis while HSP27 depletion promotes erastin-induced ferroptosis of glioblastoma. Notably, HSP27 phosphorylation is required for the protective function of HSP27 in erastin-induced ferroptosis. Overall, our study reveal novel molecular mechanisms of ferroptosis in glioma and also identify HSP27 as a negative regulator of ferroptosis and a potential target for the treatment of glioma.
铁死亡作为一种新的非凋亡性细胞死亡形式，在人类癌症中发挥着重要作用。尽管有报道称 HSP27 是癌症中铁死亡的一种新型调节因子，但 HSP27 如何影响神经胶质瘤中的铁死亡仍不清楚。在本研究中，我们研究了 HSP27 对神经胶质瘤中铁死亡的影响。HSP27 过表达可保护神经胶质瘤细胞免受 erastin 诱导的铁死亡，而 HSP27 耗竭则促进 erastin 诱导的神经胶质瘤铁死亡。值得注意的是，HSP27 磷酸化是 HSP27 在 erastin 诱导的铁死亡中发挥保护作用所必需的。总的来说，我们的研究揭示了神经胶质瘤中铁死亡的新分子机制，并确定 HSP27 是铁死亡的负调节因子和神经胶质瘤治疗的潜在靶点。
