Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004,China.
Department of Neurology, The First People's Hospital of Taicang, Suzhou 215400,China.
Curr Neurovasc Res. 2021;18(4):427-434. doi: 10.2174/1567202618666211118141803.
We investigated the combined effect of white blood cell (WBC) and platelet count on in-hospital mortality and pneumonia in acute ischemic stroke (AIS) patients.
A total of 3,265 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in the present study. We divided patients into four groups according to their level of WBC and platelet count: LWHP (low WBC and high platelet), LWLP (low WBC and low platelet), HWHP (high WBC and high platelet), and HWLP (high WBC and low platelet). A logistic regression model was used to estimate the combined effect of WBC and platelet counts on all-cause in-hospital mortality and pneumonia in AIS patients.
HWLP was associated with a 2.07-fold increase in the risk of in-hospital mortality in comparison to LWHP (adjusted odds ratio (OR) 2.07; 95% confidence interval (CI), 1.02-4.18; P-trend =0.020). The risk of pneumonia was significantly higher in patients with HWLP than those with LWHP (adjusted OR 2.29; 95% CI, 1.57-3.35; P-trend <0.001). The C-statistic for the combined WBC and platelet count was higher than WBC count or platelet count alone for the prediction of in- -hospital mortality and pneumonia (all P < 0.01).
High WBC count combined with a low platelet count level at admission was independently associated with in-hospital mortality and pneumonia in AIS patients. Moreover, the combination of WBC count and platelet count level appeared to be a better predictor than WBC count or platelet count alone.
本研究旨在探讨白细胞（WBC）和血小板计数联合对急性缺血性脑卒中（AIS）患者住院期间死亡率和肺炎的影响。
本研究共纳入 2013 年 12 月至 2014 年 5 月苏州 22 家医院的 3265 例 AIS 患者。根据 WBC 和血小板计数水平，将患者分为四组：LWHP（低 WBC 和高血小板）、LWLP（低 WBC 和低血小板）、HWHP（高 WBC 和高血小板）和 HWLP（高 WBC 和低血小板）。采用 logistic 回归模型估计 WBC 和血小板计数联合对 AIS 患者全因住院期间死亡率和肺炎的影响。
与 LWHP 相比，HWLP 患者住院期间死亡率的风险增加了 2.07 倍（调整后的优势比（OR）2.07；95%置信区间（CI）1.02-4.18；P 趋势=0.020）。HWLP 患者肺炎的风险明显高于 LWHP 患者（调整后的 OR 2.29；95%CI，1.57-3.35；P 趋势<0.001）。与 WBC 计数或血小板计数单独预测住院期间死亡率和肺炎相比，联合 WBC 和血小板计数的 C 统计量更高（均 P<0.01）。
入院时高 WBC 计数伴低血小板计数水平与 AIS 患者住院期间死亡率和肺炎独立相关。此外，WBC 计数和血小板计数水平的联合似乎比 WBC 计数或血小板计数单独更能预测。
