Promyelocytic blast crisis of Philadelphia-positive thrombocythemia with translocations (9;22) and (15;17).

作者信息

Laï J L, Fenaux P, Zandecki M, Savary J B, Estienne M H, Jouet J P, Bauters F, Deminatti M

机构信息

Service de Génétique, Faculté de Médecine, Hôpital Calmette, Lille, France.

出版信息

Cancer Genet Cytogenet. 1987 Dec;29(2):311-4. doi: 10.1016/0165-4608(87)90241-x.

We report a promyelocytic blast crisis in a case of Ph-positive thrombocythemia with both t(9;22) and t(15;17). Our patient confirms the specificity of t(15;17) in malignant proliferation of promyelocytes and suggests its appearance as a second genetic event in the genesis of blast crisis occurring in a Ph-positive clone.