非洲爪蟾卵中定位于植物半球的一种母源mRNA编码一种与转化生长因子β相关的生长因子。

A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.

作者信息

Weeks D L, Melton D A

机构信息

Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.

出版信息

Cell. 1987 Dec 4;51(5):861-7. doi: 10.1016/0092-8674(87)90109-7.

DOI:10.1016/0092-8674(87)90109-7

PMID:3479264

Abstract

We report that Vg1, a maternal mRNA localized to the vegetal hemisphere of frog eggs, encodes a member of the transforming growth factor-beta (TGF-beta) family of proteins. Furthermore, we show that Vg1 mRNA is distributed to presumptive endodermal cells after fertilization. Previous studies had shown that the vegetal end of a frog egg produces a signal that induces the overlying animal pole cells to form mesodermal tissue. More recently it has been shown that fibroblast growth factor (FGF) and TGF-beta can participate in the induction of muscle. Together, these results lead us to propose that the formation of mesoderm during frog development is specified by the products of localized maternal mRNAs, including Vg1.

摘要

我们报告称，Vg1是一种定位于蛙卵植物半球的母体mRNA，它编码转化生长因子-β（TGF-β）蛋白家族的一个成员。此外，我们发现Vg1 mRNA在受精后分布到预定的内胚层细胞中。先前的研究表明，蛙卵的植物端会产生一种信号，诱导覆盖其上的动物极细胞形成中胚层组织。最近有研究表明，成纤维细胞生长因子（FGF）和TGF-β可参与肌肉的诱导。综合这些结果，我们提出蛙发育过程中中胚层的形成是由包括Vg1在内的定位母体mRNA的产物所决定的。