Deshler J O, Highett M I, Schnapp B J
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
Science. 1997 May 16;276(5315):1128-31. doi: 10.1126/science.276.5315.1128.
In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.
在许多生物体中，胚胎中的模式形成源于卵子中信使核糖核酸（mRNA）的极化分布。在非洲爪蟾中，编码Vg1（一种参与中胚层诱导的生长因子）的mRNA定位于卵母细胞的植物性皮质。一种名为Vera的蛋白质被证明与Vg1 mRNA的定位有关。Vera与内质网（ER）膜共分离，并且内源性Vg1 mRNA与内质网的一个亚区室相关联。Vera可能通过介导Vg1 3'非翻译区与内质网亚区室之间的相互作用来促进非洲爪蟾卵母细胞中的mRNA定位。
