Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Neuron. 2021 Nov 17;109(22):3537-3539. doi: 10.1016/j.neuron.2021.10.027.
Accumulating evidence supports the prevalence of experience-dependent oligodendrocyte precursor cell (OPC) differentiation and myelination in learning and memory. However, the mechanisms remain unknown. In this issue of Neuron, Osso et al., (2021) report that stress causes the secretion of dynorphin by unmyelinated axons, which induces OPC differentiation and myelination of neighboring axons.
越来越多的证据支持经验依赖性少突胶质前体细胞（OPC）分化和髓鞘形成在学习和记忆中的普遍性。然而，其机制尚不清楚。在本期《神经元》杂志上，Osso 等人报告说，应激导致未髓鞘化轴突分泌强啡肽，从而诱导邻近轴突的 OPC 分化和髓鞘形成。
