Panda Suman, Chatterjee Oishika, Roy Laboni, Chatterjee Subhrangsu
Department of Biophysics, Bose Institute, P-1/12 CIT Road, Scheme VIIM, Kankurgachi, Kolkata 700054, India.
Department of Biophysics, Bose Institute, P-1/12 CIT Road, Scheme VIIM, Kankurgachi, Kolkata 700054, India.
Drug Discov Today. 2022 Mar;27(3):923-934. doi: 10.1016/j.drudis.2021.11.012. Epub 2021 Nov 15.
The drug resistance of cancer cells is a major concern in medical oncology, resulting in the failure of chemotherapy. Ca plays a pivotal role in inducing multidrug resistance in cancer cells. Calcium signaling is a critical regulator of many cancer hallmarks, such as angiogenesis, invasiveness, and migration. In this review, we describe the involvement of Ca signaling and associated proteins in cancer progression and in the development of multidrug resistance in cancer cells. We also highlight the possibilities and challenges of targeting the Ca channels, transporters, and pumps involved in Ca signaling in cancer cells through structure-based drug design. This work will open a new therapeutic window to be used against cancer in upcoming years.
癌细胞的耐药性是医学肿瘤学中的一个主要问题，会导致化疗失败。钙在诱导癌细胞多药耐药中起关键作用。钙信号是许多癌症特征（如血管生成、侵袭和迁移）的关键调节因子。在本综述中，我们描述了钙信号及相关蛋白在癌症进展和癌细胞多药耐药发展中的作用。我们还强调了通过基于结构的药物设计靶向参与癌细胞钙信号的钙通道、转运体和泵的可能性与挑战。这项工作将为未来几年对抗癌症打开一个新的治疗窗口。
