硫霉素半胱胺侧链的修饰。III.
Modification of the cysteamine side chain of thienamycin. III.
作者信息
Sato M, Takemura M, Atarashi S, Higashi K, Nagahara T, Furukawa M, Ikeuchi T, Osada Y
机构信息
Laboratory of Medicinal Chemistry, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1987 Sep;40(9):1292-302. doi: 10.7164/antibiotics.40.1292.
PMID:3479415
Abstract
Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the antimicrobial activity of these compounds were determined. Their structure-activity relationships are also discussed.
摘要
制备了在C-2位具有环脒部分的硫霉素衍生物（4）。测定了这些化合物对肾脱氢肽酶-1的敏感性和抗菌活性。还讨论了它们的构效关系。
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