Klietmann W, Focht J, Nösner K
Institut für Labormedizin, Fed. Rep. of Germany.
Chemioterapia. 1987 Aug;6(4):243-50.
Imipenem is a thienamycin antibiotic of the first generation with broad antibacterial activity. It covers all gram-positive organisms (including Streptococcus faecalis) and gram-negative bacteria (including Pseudomonas aeruginosa and Serratia spp.) as well as Bacteroides fragilis and other Bacteroides species. In this comparative study the antimicrobic effect against 1020 gram-negative, 927 gram-positive and 352 anaerobic strains from fresh clinical isolates was tested and compared with that of other frequently used antibiotics. The minimum inhibitory concentrations (MIC) were determined by means of a serial dilution test with micro standard plates. Within the group of gram-negative strains, imipenem was the most active antibiotic with a MIC90 of less than or equal to 0.25 mg/l for most isolates. Imipenem shows a broad spectrum of activity against gram-negative pathogenic bacteria including Escherichia coli, Klebsiella spp., Proteus spp, Enterobacter spp., Citrobacter spp. and Serratia spp., and also covers resistant strains of Pseudomonas aeruginosa, Acinetobacter spp. and Alcaligenes faecalis. Imipenem also shows high inhibiting activity against gram-positive strains and anaerobic pathogens.
亚胺培南是第一代硫霉素类抗生素，具有广泛的抗菌活性。它涵盖所有革兰氏阳性菌（包括粪肠球菌）、革兰氏阴性菌（包括铜绿假单胞菌和沙雷氏菌属）以及脆弱拟杆菌和其他拟杆菌属。在这项比较研究中，测试了亚胺培南对来自新鲜临床分离株的1020株革兰氏阴性菌、927株革兰氏阳性菌和352株厌氧菌的抗菌效果，并与其他常用抗生素进行了比较。最低抑菌浓度（MIC）通过微量标准平板系列稀释试验测定。在革兰氏阴性菌组中，亚胺培南是活性最强的抗生素，大多数分离株的MIC90小于或等于0.25mg/L。亚胺培南对包括大肠杆菌、克雷伯菌属、变形杆菌属、肠杆菌属、柠檬酸杆菌属和沙雷氏菌属在内的革兰氏阴性病原菌具有广谱活性，还涵盖铜绿假单胞菌、不动杆菌属和粪产碱杆菌的耐药菌株。亚胺培南对革兰氏阳性菌和厌氧病原菌也显示出高抑制活性。
