从疟疾疫苗模型中获得的政策决策见解：关注 RTS,S。
Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S.
机构信息
Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.
University of Basel, 4001, Basel, Switzerland.
出版信息
Malar J. 2021 Nov 18;20(1):439. doi: 10.1186/s12936-021-03973-y.
Abstract
Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed product, RTS,S/AS01. The main contributions of modelling studies have been in inferring the mechanism of action and efficacy profile of RTS,S; to predicting the public health impact; and economic modelling mainly comprising cost-effectiveness analysis. The value of both product-specific and generic modelling of vaccines is highlighted.
摘要
数学模型越来越多地用于指导从临床前研究到国家实施新型卫生干预措施的整个产品开发过程中的决策。本综述通过回顾疟疾疫苗建模方面的文献，重点介绍其与首个获得许可的产品 RTS,S/AS01 的政策指导制定的联系，说明了模拟方法的实用性。建模研究的主要贡献在于推断 RTS,S 的作用机制和疗效特征；预测公共卫生影响；以及主要包括成本效益分析的经济建模。突出了疫苗特定产品和通用模型的价值。
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Cost-effectiveness and public health impact of RTS,S/AS01 malaria vaccine in Malawi, using a Markov static model.使用马尔可夫静态模型评估RTS,S/AS01疟疾疫苗在马拉维的成本效益和对公共卫生的影响
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