Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taipei, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
J Am Acad Dermatol. 2022 Oct;87(4):771-778. doi: 10.1016/j.jaad.2021.10.045. Epub 2021 Nov 1.
Growing evidence has revealed abnormalities in the retinal structures of patients with alopecia areata (AA). However, the relationship between AA and retinopathy remains unclear.
To investigate the association between AA and retinal diseases.
The study participants were recruited from the National Health Insurance Research Database in Taiwan. We included 9909 patients with AA and 99,090 matched controls to assess the risk of retinal diseases. A Cox regression model was used for all analyses.
Compared with the controls, patients with AA had an adjusted hazard ratio (aHR) of 3.10 (95% confidence interval [CI] 2.26-4.26) for retinal diseases. With respect to individual retinal diseases, Patients with AA had significantly higher risks of developing retinal detachment (aHR 3.98; 95% CI 2.00-7.95), retinal vascular occlusion (aHR 2.45; 95% CI 1.22-4.92), and retinopathy (aHR 3.24; 95% CI 2.19-4.81) than controls.
This was a retrospective cohort study. Meanwhile, almost all the participating individuals were residents of Taiwan; therefore, the validity of our findings in other demographics remains unclear.
Patients with AA had a significantly higher risk of retinal disease than controls. Further studies are needed to clarify the pathophysiology of AA and retinal diseases.
越来越多的证据表明，斑秃（AA）患者的视网膜结构存在异常。然而，AA 与视网膜病变之间的关系尚不清楚。
探讨 AA 与视网膜疾病之间的关联。
研究对象来自台湾的全民健康保险研究数据库。我们纳入了 9909 例 AA 患者和 99090 例匹配对照，以评估视网膜疾病的风险。所有分析均采用 Cox 回归模型。
与对照组相比，AA 患者发生视网膜疾病的调整后危险比（aHR）为 3.10（95%置信区间 [CI] 2.26-4.26）。就个别视网膜疾病而言，AA 患者发生视网膜脱离（aHR 3.98；95% CI 2.00-7.95）、视网膜血管闭塞（aHR 2.45；95% CI 1.22-4.92）和视网膜病变（aHR 3.24；95% CI 2.19-4.81）的风险显著高于对照组。
这是一项回顾性队列研究。同时，几乎所有参与的个体都是台湾居民；因此，我们的发现在其他人群中的有效性尚不清楚。
AA 患者发生视网膜疾病的风险明显高于对照组。需要进一步研究阐明 AA 和视网膜疾病的病理生理学。
