斑秃与肠易激综合征的双向关联：一项全国基于人群的队列研究。
Bidirectional association between alopecia areata and irritable bowel syndrome: A nationwide population-based cohort study.
机构信息
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
出版信息
Australas J Dermatol. 2022 May;63(2):e127-e132. doi: 10.1111/ajd.13809. Epub 2022 Feb 23.
BACKGROUND
Alopecia areata (AA) and irritable bowel syndrome (IBS) are two distinct diseases that share a similar pathophysiology; however, the relationship between these two diseases is unknown. This study aimed to investigate the bidirectional relationship between AA and IBS.
METHODS
Participants were recruited from the National Health Insurance Research Database in Taiwan. We included 5446 patients with AA and 21 784 matched controls to assess the risk of IBS, and 56 429 patients with IBS and 225 716 matched controls to assess the risk of AA. The Cox proportional-hazards regression model was used to calculate the adjusted hazard ratio (aHR).
RESULTS
After adjustment for potential confounders, patients with AA had an aHR of 5.20 [95% confidence interval (CI) 3.97-6.82] for IBS in comparison with the controls. Furthermore, compared with the controls, IBS patients had an aHR of 5.38 (95% CI 3.95-7.34) for AA.
CONCLUSION
AA is bidirectionally associated with IBS. Further investigation is needed to elucidate the shared pathogenesis underlying these two diseases.
背景
斑秃（AA）和肠易激综合征（IBS）是两种截然不同的疾病，它们具有相似的病理生理学；然而，这两种疾病之间的关系尚不清楚。本研究旨在探讨 AA 和 IBS 之间的双向关系。
方法
参与者从台湾全民健康保险研究数据库中招募。我们纳入了 5446 名 AA 患者和 21784 名匹配对照，以评估 IBS 的发病风险，纳入了 56429 名 IBS 患者和 225716 名匹配对照，以评估 AA 的发病风险。采用 Cox 比例风险回归模型计算调整后的危险比（aHR）。
结果
调整潜在混杂因素后，与对照组相比，AA 患者患 IBS 的 aHR 为 5.20（95%CI 3.97-6.82）。此外，与对照组相比，IBS 患者患 AA 的 aHR 为 5.38（95%CI 3.95-7.34）。
结论
AA 与 IBS 呈双向关联。需要进一步研究阐明这两种疾病的共同发病机制。
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