Department of Anaesthesiology and Intensive Care Medicine, General Hospital Vinkovci, Vinkovci, Croatia.
Psychiatr Danub. 2021 Fall;33(3):283-286. doi: 10.24869/psyd.2021.283.
Data on the potential connection between surgical stress during caesarean section and the role of heat shock proteins in development of postpartal depression is lacking in the literature. This is a narrative review with a goal to establish the potential role of heat shock proteins during caesarean section and development of postpartal depression. Systemic hyperinflammatory state, such as the one that occurs during surgery, may trigger protective cell reaction, which is usually called the heat shock response. Results of several researches bring strong evidence of correlation between expression of genes coding for family of heat shock proteins with the onset of depressive symptoms. Also, a recent meta-analysis established caesarean section as a risk factor for development of postpartal depression. It is obvious that heat shock proteins play a certain role in development of psychiatric disorders. However, a role of heat shock proteins in development of postpartal depression remains open for debate. We emphasise the need for a randomised control trial which would enable an answer to the mentioned issue.
关于剖宫产手术应激与热休克蛋白在产后抑郁症发展中的作用之间的潜在联系的数据在文献中尚缺乏。这是一篇叙述性综述，旨在确定热休克蛋白在剖宫产术和产后抑郁症发展中的潜在作用。全身炎症状态，如手术过程中发生的炎症状态，可能会引发保护性细胞反应，通常称为热休克反应。几项研究的结果为基因表达与热休克蛋白家族编码与抑郁症状发作之间的相关性提供了有力的证据。此外，最近的一项荟萃分析将剖宫产术确立为产后抑郁症发展的危险因素。很明显，热休克蛋白在精神疾病的发展中起一定作用。然而，热休克蛋白在产后抑郁症发展中的作用仍存在争议。我们强调需要进行随机对照试验，以回答上述问题。
