Andrija Stampar Teaching Institute of Public Health, Mirogojska cesta 16, 10000 Zagreb, Croatia,
Psychiatr Danub. 2021 Fall;33(3):334-341. doi: 10.24869/psyd.2021.334.
There are only a few studies in patients with haemophilia (PWH) that examined both quality of life and depressive symptoms, with only few studies examining their association. Aim of this study was to examine the association between depressive symptoms and health-related quality of life (HRQoL) in PWH from Croatia and Slovenia.
A total of 112 adult PWH on prophylactic (73%) or on-demand (27%) treatment were included in the study (median age 46 years, range 18-73 years). Depressive symptoms were assessed with BDI-II, HRQoL with SF-36v2, demographic and socioeconomic data were collected using a questionnaire, and clinical data were obtained from medical records.
All HRQoL scores were significantly negatively correlated with BDI-II in the -0.42 to -0.70 range (all p<0.05). Socio-demographic and clinical variables explained 28-51% of HRQoL variance scores. Depressive symptoms explained additional variance for six HRQoL domain scores, with incremental variance being larger for mental domain scores (ranging between 10-27%), and for Mental Component Summary score (26%).
This study's findings support that having depressive symptoms is associated with HRQoL of PWH, more so in the mental health than in the physical health domains.
仅有少数针对血友病患者（PWH）的研究同时考察了生活质量和抑郁症状，且仅有少数研究考察了它们之间的关联。本研究旨在检验克罗地亚和斯洛文尼亚 PWH 中抑郁症状与健康相关生活质量（HRQoL）之间的关联。
共纳入 112 名接受预防性（73%）或按需（27%）治疗的成年 PWH（中位数年龄 46 岁，范围 18-73 岁）。使用 BDI-II 评估抑郁症状，使用 SF-36v2 评估 HRQoL，使用问卷收集人口统计学和社会经济学数据，并从病历中获取临床数据。
HRQoL 各维度评分与 BDI-II 评分呈显著负相关（范围为-0.42 至-0.70，均 p<0.05）。社会人口统计学和临床变量解释了 HRQoL 变异评分的 28-51%。抑郁症状可解释六个 HRQoL 维度评分的额外变异，精神健康维度评分的增量变异较大（10-27%），心理成分综合评分的增量变异最大（26%）。
本研究结果支持抑郁症状与 PWH 的 HRQoL 相关，在精神健康领域比在身体健康领域更为显著。
