Andrija Stampar Teaching Institute of Public Health, Zagreb, Croatia.
Faculty of Humanities and Social Sciences, University of Zagreb, Zagreb, Croatia.
Int J Clin Pharm. 2021 Dec;43(6):1500-1507. doi: 10.1007/s11096-021-01270-x. Epub 2021 Apr 29.
Background Medication adherence is an important issue, not just health-related, for patients with haemophilia. Poor medication adherence to long-term therapies limits the potential of effective treatments to improve patients' health-related quality of life. Objective The aim of this study was to investigate the association of reported medication adherence and health-related quality of life in patients with haemophilia. Setting Data were collected from patients at University Hospital Centre Zagreb, Croatia and at University Medical Centre Ljubljana, Slovenia. Method Adult male patients with severe or moderate haemophilia receiving prophylactic treatment were eligible for the study. Main outcome measure Implementation phase of medication adherence was assessed with the self-reported VERITAS-Pro instrument and health-related quality of life with SF-36v2. Results A total of 82 participants were included in the study (median age was 44.50, range 18-73 years). The majority of our participants reported being adherent to medication (83%). Participants showed better health in the mental health domains and Mental Component Summary than in the physical health domains and Physical Component Summary. After controlling for demographic, socioeconomic and clinical predictors, better reported medication adherence explained an additional 4-6% of better health variance in Bodily Pain and Social Functioning domains and Mental Component Summary. Conclusion We found that reported medication adherence can contribute to better health-related quality of life in patients with haemophilia. Since life with a chronic condition is demanding, it is an important finding that medication adherence to replacement therapy can improve life conditions for patients with haemophilia.
药物依从性不仅与健康相关，对血友病患者而言也是一个重要问题。长期治疗药物依从性差会限制有效治疗改善患者健康相关生活质量的潜力。目的：本研究旨在探讨报告的药物依从性与血友病患者健康相关生活质量的关系。地点：数据来自克罗地亚萨格勒布大学医院中心和斯洛文尼亚卢布尔雅那大学医学中心的患者。方法：接受预防性治疗的严重或中度血友病成年男性患者有资格参加本研究。主要观察指标：药物依从性的实施阶段采用自我报告的 VERITAS-Pro 工具评估，健康相关生活质量采用 SF-36v2 评估。结果：共有 82 名参与者纳入研究（中位年龄为 44.50 岁，范围为 18-73 岁）。我们的大多数参与者报告药物依从性良好（83%）。与生理健康领域和生理成分综合评分相比，参与者在心理健康领域和精神成分综合评分中表现出更好的健康状况。在控制人口统计学、社会经济和临床预测因素后，报告的药物依从性更好解释了身体疼痛和社会功能领域以及精神成分综合评分中更好健康状况的额外 4-6%的差异。结论：我们发现报告的药物依从性可以提高血友病患者的健康相关生活质量。由于慢性病的生活要求很高，因此治疗药物的依从性可以改善血友病患者的生活条件，这是一个重要的发现。
