Nickell W T, Shipley M T
Department of Anatomy and Cell Biology, University of Cincinnati, College of Medicine, Ohio.
J Neural Transm Suppl. 1987;24:153-60.
We have used the cholinergic projection from the nucleus of the horizontal limb of the diagonal band (HDB) to the olfactory bulb as a model for studying the neurophysiology of cholinergic projections from the basal forebrain to cortical structures. Although single shocks to HDB have little effect upon function of the target structure, short periods of repetitive stimulation produce profound changes. These observations are discussed in terms of the known physiology of central cholinergic systems and the significance of cholinergic synaptic potentiation for Alzheimer's disease.
我们利用从斜角带水平支核（HDB）到嗅球的胆碱能投射作为模型，来研究从基底前脑到皮质结构的胆碱能投射的神经生理学。尽管对HDB进行单次电击对靶结构的功能影响很小，但短时间的重复刺激会产生深刻的变化。根据中枢胆碱能系统的已知生理学以及胆碱能突触增强对阿尔茨海默病的意义对这些观察结果进行了讨论。
