Ross M S, Moldofsky H
Am J Psychiatry. 1978 May;135(5):585-7. doi: 10.1176/ajp.135.5.585.
In a double-blind placebo-controlled study, both pimozide and haloperidol significantly decreased tic frequency in nine patients with Gilles de la Tourette's syndrome. These findings are consistent with the catecholamine hypothesis of tic generation. Pimozide was associated with significantly fewer complaints of lethargy. Follow-up 4-20 months later showed that six of seven patients receiving pimozide and one of two receiving haloperidol had had greater than 75% improvement in symptoms.
在一项双盲安慰剂对照研究中，匹莫齐特和氟哌啶醇均显著降低了9例抽动秽语综合征患者的抽动频率。这些发现与抽动产生的儿茶酚胺假说一致。匹莫齐特引起的嗜睡主诉明显较少。4至20个月后的随访显示，接受匹莫齐特治疗的7例患者中有6例、接受氟哌啶醇治疗的2例患者中有1例症状改善超过75%。
