McDowell K J, Sharp D C, Grubaugh W
Department of Animal Science, University of Florida, Gainesville 32611.
J Reprod Fertil Suppl. 1987;35:335-42.
Eight ovariectomized pony mares were used to test the effect of various doses of progesterone (0, 50, 150, 450 mg/day, in oil, i.m., for 10 days) on progesterone and LH in the peripheral circulation, and on total protein and uteroferrin in uterine secretions. Progesterone increased uteroferrin, but there were no differences amongst doses of progesterone. Progesterone treatment decreased LH, and tended to increase total protein. Eighteen ovariectomized mares were given vehicle, oestradiol (10 mg/day, in oil, i.m.), progesterone or progesterone + oestradiol for 28 days. Both the last two steroid treatments significantly increased total protein and uteroferrin in the uterine secretions, compared to vehicle or oestradiol alone. Progesterone + oestradiol increased uteroferrin, but not total protein compared to progesterone. Nine ovariectomized progesterone-primed mares were used to compare systemic and intraluminal administration of oestradiol. There were no differences between routes of administration of oestradiol. In conclusion, administration of progesterone increased total protein and uteroferrin in uterine secretions, and progesterone + oestradiol increased them further.
八匹去卵巢的母马被用于测试不同剂量的孕酮（0、50、150、450毫克/天，油剂，肌肉注射，共10天）对外周循环中孕酮和促黄体生成素（LH），以及子宫分泌物中总蛋白和子宫铁蛋白的影响。孕酮可增加子宫铁蛋白，但不同剂量的孕酮之间没有差异。孕酮治疗可降低LH，并倾向于增加总蛋白。十八匹去卵巢的母马接受载体、雌二醇（10毫克/天，油剂，肌肉注射）、孕酮或孕酮+雌二醇治疗28天。与单独使用载体或雌二醇相比，后两种类固醇治疗均显著增加了子宫分泌物中的总蛋白和子宫铁蛋白。与孕酮相比，孕酮+雌二醇增加了子宫铁蛋白，但未增加总蛋白。九匹经孕酮预处理的去卵巢母马被用于比较雌二醇的全身给药和腔内给药。雌二醇的给药途径之间没有差异。总之，孕酮给药可增加子宫分泌物中的总蛋白和子宫铁蛋白，而孕酮+雌二醇可使其进一步增加。
