Researcher, Laboratory of Clinical Neurophysiology; Federal Clinical Research Centre for Intensive Care Medicine and Rehabilitology, 777 Lytkino Village, Solnechnogorsk District, Moscow Region, 141534, Russia.
Junior Researcher, Laboratory of Clinical Neurophysiology; Federal Clinical Research Centre for Intensive Care Medicine and Rehabilitology, 777 Lytkino Village, Solnechnogorsk District, Moscow Region, 141534, Russia.
Sovrem Tekhnologii Med. 2021;12(5):94-104. doi: 10.17691/stm2020.12.5.11. Epub 2020 Oct 28.
The review analyzes current clinical studies on the use of therapeutic hypothermia as a neuroprotective method for treatment of brain damage. This method yields good outcomes in patients with acute brain injuries and chronic critical conditions. There has been shown the interest of researchers in studying the preventive potential of therapeutic hypothermia in secondary neuronal damage. There has been described participation of new molecules producing positive effect on tissues and cells of the central nervous system - proteins and hormones of cold stress - in the mechanisms of neuroprotection in the brain. The prospects of using targeted temperature management in treatment of brain damage are considered.
本文回顾了临床研究中使用治疗性低温作为脑损伤治疗的神经保护方法的现状。该方法在急性脑损伤和慢性危重病患者中均取得了良好的效果。研究人员对研究治疗性低温在继发性神经元损伤中的预防潜力表现出了浓厚的兴趣。已经描述了在脑的神经保护机制中，新的分子参与产生对中枢神经系统组织和细胞的积极影响，如冷应激蛋白和激素。还考虑了靶向温度管理在脑损伤治疗中的应用前景。
