Shu Juntao, Liu Ling, Yuan Mei, Ma Mingbiao, Yang Jingjing
Department of Neonatology, The Children's Hospital of Kunming City, The Affiliated Children's Hospital of Kunming Medical University, Kunming, Yunnan, China.
Department of Clinical Laboratory, The Children's Hospital of Kunming City, The Affiliated Children's Hospital of Kunming Medical University, Kunming, Yunnan, China.
Front Pediatr. 2025 Jul 28;13:1611345. doi: 10.3389/fped.2025.1611345. eCollection 2025.
Neonatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of neonatal morbidity and mortality worldwide, necessitating the exploration of effective therapeutic interventions. Current treatment strategies primarily involve therapeutic hypothermia (TH); however, its efficacy remains inconsistent. Research topics and trends in this area remain unclear as well. This study aimed to identify key research areas, collaboration networks, and emerging trends using bibliometric analysis tools.
A comprehensive analysis was conducted on 1,165 records from the Web of Science Core Collection (WoSCC) database. Various bibliometric techniques were employed, including coauthor analysis, co-occurrence analysis, co-citation analysis, reference clustering, and topic modeling, to visualize the knowledge structure and research dynamics in the HIE field.
The findings revealed extensive collaboration networks among authors, institutions, and countries, highlighting global efforts to address this critical neonatal condition. Recent trends identified key research areas, including TH, mild systemic hypothermia, oxidative stress, biomarkers and signaling pathways, which are essential for advancing the understanding and treatment of HIE.
This study provides valuable insights into the current TH for neonates with HIE. Future research should focus on optimizing treatment approaches and evaluating long-term efficacy to enhance clinical applications.
新生儿缺氧缺血性脑病（HIE）仍是全球新生儿发病和死亡的重要原因，因此有必要探索有效的治疗干预措施。目前的治疗策略主要包括治疗性低温（TH）；然而，其疗效仍不一致。该领域的研究主题和趋势也仍不明确。本研究旨在使用文献计量分析工具确定关键研究领域、合作网络和新兴趋势。
对来自科学引文索引核心合集（WoSCC）数据库的1165条记录进行了全面分析。采用了各种文献计量技术，包括合著者分析、共现分析、共被引分析、参考文献聚类和主题建模，以可视化HIE领域的知识结构和研究动态。
研究结果揭示了作者、机构和国家之间广泛的合作网络，突出了全球为解决这一关键新生儿疾病所做的努力。近期趋势确定了关键研究领域，包括TH、轻度全身低温、氧化应激、生物标志物和信号通路，这些对于增进对HIE的理解和治疗至关重要。
本研究为目前针对HIE新生儿的TH提供了有价值的见解。未来的研究应侧重于优化治疗方法和评估长期疗效，以加强临床应用。
