Kuroda K, Terao K, Akao M
Department of Toxicology and Experimental Pathology, Chiba University, Japan.
J Natl Cancer Inst. 1987 Nov;79(5):1047-51.
An inhibitory effect of fumaric acid (FA) on hepatocarcinogenesis was examined in rats fed thioacetamide (TAA). A group of male DONRYU rats were fed TAA at a level of 0.035% in the diet for 40 weeks and then fed a basal diet for 40 weeks. Hepatic carcinomas developed in 9 of 41 animals of this group fed TAA alone. The effect of FA on the carcinogenesis was examined in 2 groups fed both TAA and FA; one group of rats were fed FA at 1% in a basal diet after ingestion of TAA, and another group of rats were fed TAA plus a supplement of 1% FA in the diet. The inhibitory effect of FA on TAA carcinogenesis was so marked that no hepatic carcinomas were found in both groups fed FA in combination with TAA.
在喂食硫代乙酰胺（TAA）的大鼠中检测了富马酸（FA）对肝癌发生的抑制作用。一组雄性DONRYU大鼠在饮食中以0.035%的水平喂食TAA 40周，然后喂食基础饮食40周。仅喂食TAA的该组41只动物中有9只发生了肝癌。在两组同时喂食TAA和FA的大鼠中检测了FA对致癌作用的影响；一组大鼠在摄入TAA后在基础饮食中以1%的水平喂食FA，另一组大鼠在饮食中喂食TAA加1%的FA补充剂。FA对TAA致癌作用的抑制作用非常显著，在两组同时喂食FA和TAA的大鼠中均未发现肝癌。
