Togei K, Sano N, Maeda T, Shibata M, Otsuka H
Second Department of Pathology, School of Medicine, University of Tokushima, Japan.
J Natl Cancer Inst. 1987 Nov;79(5):1151-8.
The carcinogenicity of bucetin [(3-hydroxy-p-butyrophenetidide) CAS: 1083-57-4], an antipyretic analgesic drug, was examined in 300 (C57BL/6 X C3H)F1 mice. Groups of 50 mice of each sex were treated with 1.5 or 0.75% bucetin in their basal diet for 76 weeks and then fed a basal diet for 8 weeks. Control groups were given a basal diet for 84 weeks. In 10 of 46 (22%) male mice given the high dose of bucetin and in 6 of 45 (13%) given the low dose, renal cell tumors were induced. Dysplastic lesions of the proximal tubules were frequently seen in the males given bucetin in a dose-related fashion. Neither tumorous nor preneoplastic lesions developed in the kidneys of bucetin-treated female mice and control animals. Papilloma of the urinary bladder in 1 male mouse and papillary or nodular hyperplasia in 9 mice of both sexes were observed in groups given the high dose of bucetin.
对一种解热镇痛药布西丁（3-羟基-对丁酰苯乙胺，化学物质登记号：1083-57-4）的致癌性进行了研究，实验对象为300只（C57BL/6×C3H）F1小鼠。每组50只不同性别的小鼠，在基础饲料中添加1.5%或0.75%的布西丁，连续喂养76周，之后再喂8周基础饲料。对照组连续84周喂食基础饲料。在给予高剂量布西丁的46只雄性小鼠中，有10只（22%）诱发了肾细胞肿瘤；在给予低剂量布西丁的45只雄性小鼠中，有6只（13%）诱发了肾细胞肿瘤。给予布西丁的雄性小鼠中，近端肾小管发育异常病变呈剂量相关。给予布西丁的雌性小鼠和对照动物的肾脏均未出现肿瘤性或肿瘤前病变。给予高剂量布西丁的组中，观察到1只雄性小鼠发生膀胱乳头状瘤，9只不同性别的小鼠出现乳头状或结节状增生。
