Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA, 19104, USA.
Veterans Affairs Medical Center San Francisco, California, Department of Dermatology, University of California San Francisco, San Franciso, California, 150 Clement Street, Dermatology MS 190, San Francisco, CA, 94121, USA.
Vet Dermatol. 2021 Dec;32(6):567-e154. doi: 10.1111/vde.13033.
The stratum corneum (SC), the outermost layer of the epidermis, serves a crucial role in maintaining body hydration and protection from environmental insults. When the stratum corneum is injured or when the genetic blueprints are flawed, the body is at risk of dehydration, secondary infections and allergen sensitization. Advancements in veterinary dermatology have revealed a wide gamut of disease from relatively benign to lethal that specifically arise from flawed structural proteins, enzymes or lipids needed to create the corneocytes and lipid bilayers of the SC. Some conditions closely mimic their human counterparts while others are unique to the dog. This review will focus on forms of ichthyosis in the dog.
角质层（SC）是表皮的最外层，对于保持身体水分和抵御环境侵害起着至关重要的作用。当角质层受到损伤或遗传蓝图存在缺陷时，身体就会有脱水、继发感染和过敏原致敏的风险。兽医皮肤病学的进步揭示了一系列广泛的疾病，从相对良性到致命性的疾病，这些疾病专门由创造角质细胞和 SC 中的脂质双层所需的有缺陷的结构蛋白、酶或脂质引起。有些病症与人类的病症非常相似，而有些则是犬类特有的。本文将重点介绍犬类的鱼鳞病。
