Chartier Mariette J, Bolton James M, Ekuma Okechukwu, Mota Natalie, Hensel Jennifer M, Nie Yao, McDougall Chelsey
50023Department of Community Health Sciences, Rady Faculty of Health Sciences, 8664University of Manitoba, Winnipeg, Canada.
Department of Psychiatry and Community Health Sciences, Rady Faculty of Health Sciences, 8664University of Manitoba, Winnipeg, Canada.
Can J Psychiatry. 2022 Jul;67(7):512-523. doi: 10.1177/07067437211055417. Epub 2021 Nov 19.
The life course of children and adolescents with mental disorders is an important area of investigation, yet it remains understudied. This study provides a first-ever comprehensive examination of the relationship between child and adolescent mental disorders and subsequent suicidal and adverse social outcomes in early adulthood using population-based data.
De-identified administrative databases were used to create a birth cohort of 60,838 residents of Manitoba born between April 1980 to March 1985 who were followed until March 2015. Unadjusted and adjusted hazard ratios (aHRs) and odds ratios (aORs) were calculated to determine associations between physician-diagnosed mental disorders in childhood or adolescence and a range of adverse early adulthood (ages 18 to 35) outcomes.
Diagnoses of mood/anxiety disorders, attention-deficit hyperactivity disorder, substance use disorder, conduct disorder, psychotic disorder, personality disorders in childhood or adolescence were associated with having the same diagnoses in adulthood. These mental disorder diagnoses in childhood/adolescence were strongly associated with an increased risk of suicidal behaviors and adverse adult social outcomes in adulthood. Similarly, suicide attempts in adolescence conferred an increased risk in adulthood of suicide death (aHR: 3.6; 95% confidence interval [CI]: 1.9-6.9), suicide attempts (aHR: 6.2; CI: 5.0-7.6), social housing use (aHR: 1.7; CI 1.4-2.1), income assistance (aHR: 1.8; CI 1.6-2.1), criminal accusation (aHR: 2.2; CI 2.0-2.5), criminal victimization (aHR:2.5; CI 2.2-2.7), and not completing high school (aOR: 3.1; CI: 2.5-3.9).
Mental disorders diagnosed in childhood and adolescence are important risk factors not only for mental disorders in adulthood but also for a range of early adult adversity. These findings provide an evidence-based prognosis of children's long-term well-being and a rationale for ensuring timely access to mental health services. Better population-level mental health promotion and early intervention for children and adolescents with mental disorders are promising for improving future adult outcomes.
患有精神障碍的儿童和青少年的生命历程是一个重要的研究领域,但仍未得到充分研究。本研究首次使用基于人群的数据,全面考察了儿童和青少年精神障碍与成年早期随后的自杀及不良社会后果之间的关系。
使用经过去识别处理的行政数据库,创建了一个由1980年4月至1985年3月在曼尼托巴省出生的60838名居民组成的出生队列,对其随访至2015年3月。计算未调整和调整后的风险比(aHRs)及比值比(aORs),以确定儿童期或青少年期经医生诊断的精神障碍与一系列成年早期(18至35岁)不良后果之间的关联。
儿童期或青少年期被诊断为情绪/焦虑障碍、注意力缺陷多动障碍、物质使用障碍、品行障碍、精神障碍、人格障碍的患者,成年后患相同疾病的可能性更大。儿童期/青少年期的这些精神障碍诊断与成年后自杀行为风险增加及不良成人社会后果密切相关。同样,青少年期的自杀未遂会增加成年后自杀死亡(aHR:3.6;95%置信区间[CI]:1.9 - 6.9)、自杀未遂(aHR:6.2;CI:5.0 - 7.6)、使用社会住房(aHR:1.7;CI 1.4 - 2.1)、领取收入援助(aHR:1.8;CI 1.6 - 2.1)、受到刑事指控(aHR:2.2;CI 2.0 - 2.5)、成为刑事受害者(aHR:2.5;CI 2.2 - 2.7)以及未完成高中学业(aOR:3.1;CI:2.5 - 3.9)的风险。
儿童期和青少年期诊断出的精神障碍不仅是成年期精神障碍的重要风险因素,也是成年早期一系列逆境的重要风险因素。这些发现为儿童的长期幸福提供了基于证据的预后,并为确保及时获得心理健康服务提供了理论依据。更好地在人群层面促进心理健康并对患有精神障碍的儿童和青少年进行早期干预,有望改善未来的成人结局。