Department of Instrument Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Department of Rehabilitation, Shanghai General Hospital, Shanghai, China.
Comput Methods Biomech Biomed Engin. 2022 Aug;25(10):1169-1179. doi: 10.1080/10255842.2021.2005034. Epub 2021 Nov 19.
Based on the changes in phase characteristics of blood flow and pressure, enhanced external counterpulsation (EECP) reduces cardiac load and improves cerebral perfusion in patients with cerebrovascular diseases. However, increased cerebral blood flow (CBF) is associated with the rise in blood pressure and its complications. Increased EECP frequency is a valuable solution when combined with the electrical equivalent impedance characteristics of the lumped parameter model (LPM) of the human blood circulation system. Herein, to investigate the effect of different EECP frequencies on CBF perfusion, an LPM was established with cardiopulmonary circulation and eight systemic blood flow units with cerebral autoregulation module of ischemic stroke patients. Then, using differential equations, we analyzed those parameters through hemodynamic simulations in four EECP modes. With related influencing parameters remaining constant, we adjusted the pressure frequency of EECP and found that when compared to the traditional sequential EECP mode, the relative increase rate of CBF was 16.68%, 18.95%, and 21.21% from 1 to 3 Hz, respectively. This study validates the effect of improving blood prefusion with increasing EECP frequency through numerical analysis.
基于血流和压力相位特征的变化，增强型体外反搏（EECP）可降低脑血管病患者的心脏负荷并改善脑灌注。然而，脑血流量（CBF）的增加与血压升高及其并发症有关。当与人体血液循环系统的集中参数模型（LPM）的电气等效阻抗特性相结合时，增加 EECP 频率是一个有价值的解决方案。在此，为了研究不同 EECP 频率对 CBF 灌注的影响，我们使用心肺循环和 8 个全身血流单元建立了带有缺血性脑卒中患者脑自动调节模块的 LPM。然后，我们使用微分方程通过四种 EECP 模式下的血液动力学模拟来分析这些参数。在保持相关影响参数不变的情况下，我们调整了 EECP 的压力频率，结果发现，与传统的顺序 EECP 模式相比，CBF 的相对增加率分别为 1Hz、2Hz 和 3Hz 时的 16.68%、18.95%和 21.21%。本研究通过数值分析验证了通过增加 EECP 频率来改善血液预灌注的效果。
