O'Connell G J, Ryan E, Murphy K J, Prefontaine M
Department of Obstetrics-Gynecology, McMaster University, Hamilton, Ontario, Canada.
Obstet Gynecol. 1987 Dec;70(6):930-2.
Between November 1984 and May 1986, 56 patients presenting with a pelvic mass to the Gynecologic Oncology Service of McMaster University and the Hamilton Regional Oncology Center underwent laparotomy for possible ovarian cancer. All patients had blood drawn for CA 125 three days before operation. Levels above 35 U/mL were considered positive; CA 125 had a positive predictive value of 60%. False positives occurred in patients with nongynecologic malignancies and with benign gynecologic conditions. On the other hand, CA 125 had a negative predictive value of 100%, suggesting that this test may be useful in identifying those patients with pelvic masses at higher risk for malignancy, who may require transfer for surgery at a tertiary care center.
1984年11月至1986年5月期间，56名因盆腔肿块就诊于麦克马斯特大学妇科肿瘤服务部和汉密尔顿地区肿瘤中心的患者接受了剖腹手术，以排查是否患有卵巢癌。所有患者在手术前三天均采集了血液检测CA 125。35 U/mL以上的水平被视为阳性；CA 125的阳性预测值为60%。非妇科恶性肿瘤患者和妇科良性疾病患者会出现假阳性。另一方面，CA 125的阴性预测值为100%，这表明该检测可能有助于识别那些盆腔肿块恶性风险较高的患者，这些患者可能需要转至三级医疗中心进行手术。
