International Scientific Center of Extremal Organism State Research, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.
Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.
Bull Exp Biol Med. 2021 Nov;172(1):77-80. doi: 10.1007/s10517-021-05335-9. Epub 2021 Nov 19.
Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.
在静脉注射后 2.5 小时以及注射后 10、35 和 97 天，研究了纳米金刚石在小鼠体内的分布、AST 和 ALT 的活性以及血浆中胆红素的水平。静脉注射后 2.5 小时，纳米金刚石主要积聚在肺部和肝脏。然后，观察到纳米金刚石从所有器官重新分布到肝脏。AST 和 ALT 的活性以及血液中的胆红素水平在 2.5 小时后升高，然后降至初始值。
