Departments of Dermatology and Venereology, and.
Pathology, All India Institute of Medical Sciences, New Delhi, India .
Am J Dermatopathol. 2021 Dec 1;43(12):935-938. doi: 10.1097/DAD.0000000000002071.
"Line sign," "cookie cutter sign," "square biopsy sign," "high eccrine glands sign" have been previously described in morphoea and lichen sclerosus. We found focal areas of thickened collagen bundles with lymphocytes interspersed between them in several biopsies of these conditions.
We reviewed slides of sclerosing disorders obtained from the archives of the pathology department in our hospital for the period 2013-2019.
A total of 73 slides including 40 of lichen sclerosus, 24 of morphea, 2 of lichen sclerosus-morphea overlap, and 7 of systemic sclerosis were evaluated. Lymphocytes were noted between sclerotic collagen bundles in 46 (63%) slides, being most common in lichen sclerosus (80%, 32/40) followed by morphea (50%, 12/24), whereas it was seen in one case each of lichen sclerosus with morphea overlap (50%, 1/2) and systemic sclerosis (14.3%, 1/7). The finding was noted in the upper dermis in 20 of 32 (62.5%) slides of lichen sclerosus and in both the superficial and deep dermis in 11 (91.7%) of 12 slides of morphea.
Lymphocyte-peppered sclerotic collagen may be a useful histological clue to the diagnosis of lichen sclerosus, morphea, and systemic sclerosis.
“线征”、“饼干切痕征”、“方形活检征”、“高外分泌腺征”先前已在硬斑病和硬化性苔藓中描述过。我们在这些病变的几例活检中发现了局灶性胶原束增厚区，其间散布着淋巴细胞。
我们复习了我院病理科 2013-2019 年存档的硬化性疾病切片。
共评估了 73 张切片，包括 40 张硬化性苔藓、24 张硬斑病、2 张硬化性苔藓-硬斑病重叠、7 张系统性硬化症。在 46 张（63%）切片中发现了淋巴细胞位于硬化性胶原束之间，在硬化性苔藓中最为常见（80%，32/40），其次是硬斑病（50%，12/24），而在硬化性苔藓-硬斑病重叠和系统性硬化症中，各有 1 例（50%，1/2 和 14.3%，1/7）。在 32 张硬化性苔藓切片中有 20 张（62.5%）在上皮层发现该表现，在 12 张硬斑病切片中有 11 张（91.7%）在真皮浅层和深层均发现该表现。
淋巴细胞弥漫性分布于硬化性胶原中可能是硬斑病、硬斑病和系统性硬化症的有用组织学线索。
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