Shono S, Imura M, Ota M, Osaku A, Shinomiya S, Toda K
Department of Dermatology, Tokyo Teishin Hospital, Japan.
Arch Dermatol. 1991 Sep;127(9):1352-6.
Histological studies using three lectins, lens culinaris agglutinin, soybean agglutinin, and Ulex europaeus agglutinin-I, were carried out in a case of coexistent lichen sclerosus et atrophicus and morphea, five cases of morphea, and two cases of lichen sclerosus et atrophicus. The lectin staining patterns of the formaldehyde-fixed epidermis of patients with morphea were not different from those of normal epidermis, but epidermis of patients with lichen sclerosus et atrophicus showed different staining patterns. Lens culinaris agglutinin stained the basal and the spinous layers of the normal epidermis and that of patients with morphea but stained only the basal cells of the epidermis from patients with lichen sclerosus et atrophicus; epidermal Ulex europaeus agglutinin binding was observed only in the cases of lichen sclerosus et atrophicus. Moreover, in the patient with coexistent diseases, the morphea lesion showed the staining profiles of morphea and the lichen sclerosus et atrophicus lesion showed the staining patterns of lichen sclerosus et atrophicus, respectively.
我们使用三种凝集素，即刀豆球蛋白、大豆凝集素和荆豆凝集素-I，对1例硬化萎缩性苔藓与硬斑病共存病例、5例硬斑病病例和2例硬化萎缩性苔藓病例进行了组织学研究。硬斑病患者经甲醛固定的表皮的凝集素染色模式与正常表皮无异，但硬化萎缩性苔藓患者的表皮显示出不同的染色模式。刀豆球蛋白可对正常表皮及硬斑病患者的表皮基底层和棘层进行染色，但仅对硬化萎缩性苔藓患者表皮的基底细胞进行染色；仅在硬化萎缩性苔藓病例中观察到表皮荆豆凝集素结合。此外，在共存疾病患者中，硬斑病皮损呈现硬斑病的染色特征，而硬化萎缩性苔藓皮损则分别呈现硬化萎缩性苔藓的染色模式。
