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促进大脑健康:基于有效且不断发展的科学证据的战略方法中的策略。

Brain health promotion: Tactics within a strategic approach based upon valid, yet evolving scientific evidence.

机构信息

Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, 01003, USA.

Department of Biomedical & Biotechnological Sciences, School of Medicine, University of Catania, Via Santa Sofia, 97, 95125, Catania, Italy.

出版信息

Mech Ageing Dev. 2022 Jan;201:111605. doi: 10.1016/j.mad.2021.111605. Epub 2021 Nov 16.

Abstract

There is growing interest in finding ways to enhance longevity and the quality of life. This paper summarizes a vast scientific literature over the past two decades that has suggested approaches to enhancing biological resilience - and particularly neurological function - via hormetic and preconditioning processes. The employment of hormesis and preconditioning has been shown to protect biological systems from many of the effects of aging, both by sustaining structural and functional integrity, and by affording relative protection against certain types of diseases. The paper confronts the challenges - and opportunities - for society when considering possible practical use of evolving evidence about the mechanisms, processes and effects of these biological phenomena.

摘要

人们越来越关注寻找延长寿命和提高生活质量的方法。本文总结了过去二十年中大量的科学文献,这些文献提出了通过胁迫和预处理过程来增强生物弹性——特别是神经功能的方法。胁迫和预处理的应用已被证明可以通过维持结构和功能的完整性,以及提供对某些类型疾病的相对保护,来保护生物系统免受衰老的许多影响。本文探讨了在考虑这些生物现象的机制、过程和影响的证据不断发展的情况下,社会可能面临的挑战和机遇。

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