Department of Pediatrics, Division of Pediatric Rheumatology, Duke University School of Medicine, T909 Children's Health Center, DUMC Box 3212, Durham, NC 27710, USA; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Suite 1400, 680 North Lake Shore Drive, Chicago, IL 60611, USA; Department of Medicine, Northwestern University Feinberg School of Medicine, Suite 1400, 680 North Lake Shore Drive, Chicago, IL 60611, USA; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Suite 1400, 680 North Lake Shore Drive, Chicago, IL 60611, USA.
Rheum Dis Clin North Am. 2022 Feb;48(1):157-181. doi: 10.1016/j.rdc.2021.09.006. Epub 2021 Oct 29.
Cardiovascular disease risk is evident during childhood for patients with juvenile systemic lupus erythematosus, juvenile dermatomyositis, and juvenile idiopathic arthritis. The American Heart Association defines cardiovascular health as a positive health construct reflecting the sum of protective factors against cardiovascular disease. Disease-related factors such as chronic inflammation and endothelial dysfunction increase cardiovascular disease risk directly and through bidirectional relationships with poor cardiovascular health factors. Pharmacologic and nonpharmacologic interventions to improve cardiovascular health and long-term cardiovascular outcomes in children with rheumatic disease are needed.
心血管疾病风险在幼年特发性关节炎、幼年皮肌炎和幼年系统性红斑狼疮患者中已显现。美国心脏协会将心血管健康定义为一种积极的健康结构，反映了预防心血管疾病的保护因素总和。疾病相关因素，如慢性炎症和内皮功能障碍，通过与不良心血管健康因素的双向关系，直接增加心血管疾病风险。需要采取药物和非药物干预措施来改善患有风湿性疾病儿童的心血管健康和长期心血管结局。
