Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University Wexner Medical Center, 395 West 12th Avenue, Suite 200, Columbus, OH 43210, USA.
Division of Gastroenterology, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27710, USA. Electronic address: https://twitter.com/gi_sullivan.
Gastrointest Endosc Clin N Am. 2022 Jan;32(1):113-130. doi: 10.1016/j.giec.2021.08.007.
Familial adenomatous polyposis (FAP) is the development of many adenomatous colorectal polyps. Colonoscopy is recommended to start at age 10 to 12 years at intervals of 1 to 2 years. Colectomy is clearly indicated for malignancy or significant colorectal symptoms. After colectomy, endoscopic surveillance is still critical. Duodenal and gastric polyposis is also found in almost all patients with FAP. Screening with upper endoscopy and ampullary visualization is recommended, generally determined by age and staging of duodenal polyposis, but guidelines are increasingly factoring in ampullary and gastric manifestations. Surgical management of malignancy or advanced upper tract manifestations is needed.
家族性腺瘤性息肉病（FAP）是许多结直肠腺瘤性息肉的发展。建议从 10 到 12 岁开始，每 1 到 2 年进行一次结肠镜检查。结直肠切除术明确适用于恶性肿瘤或明显的结直肠症状。结直肠切除术后，内镜监测仍然至关重要。几乎所有 FAP 患者都存在十二指肠和胃息肉。建议通过上消化道内镜和壶腹可视化进行筛查，通常根据十二指肠息肉的年龄和分期确定，但指南越来越多地考虑到壶腹和胃的表现。需要对恶性肿瘤或上消化道晚期表现进行手术治疗。
