抗原检测 SARS-CoV-2 阳性结果时间的评估及其临床意义。
Evaluation and clinical implications of the time to a positive results of antigen testing for SARS-CoV-2.
机构信息
Division of Infectious Diseases, Department of Medicine, Tsukuba Medical Center Hospital, 1-3-1 Amakubo Tsukuba, Ibaraki, 3058558, Japan; Akashi Internal Medicine Clinic, 3-1-63 Asahigaoka, Kashiwara, Osaka, 5820026, Japan.
Division of Infectious Diseases, Department of Medicine, Tsukuba Medical Center Hospital, 1-3-1 Amakubo Tsukuba, Ibaraki, 3058558, Japan; Department of Infectious Diseases, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, 3058576, Japan.
出版信息
J Infect Chemother. 2022 Feb;28(2):248-251. doi: 10.1016/j.jiac.2021.10.026. Epub 2021 Nov 10.
INTRODUCTION
Antigen tests for severe acute respiratory coronavirus 2 sometimes show positive lines earlier than their specified read time, although the implication of getting the results at earlier time is not well understood.
METHODS
We prospectively collected additional nasopharyngeal samples from patients who had already tested positive for SARS-CoV-2 by reverse transcription PCR. The swab was used for an antigen test, QuickNavi™-COVID19 Ag, and the time periods to get positive results were measured.
RESULTS
In 84 of 96 (87.5%) analyzed cases, the results of QuickNavi™-COVID19 Ag were positive. The time to obtain positive results was 15.0 seconds in median (inter quartile range: 12.0-33.3, range 11-736) and was extended in samples with higher cycle thresholds (p < 0.001). Positive lines appeared within a minute in 85.7% of cases and within 5 min in 96.4%.
CONCLUSION
QuickNavi™-COVID19 Ag immediately showed positive results in most cases, and the time to a positive reaction may have indicated the viral load.
简介
针对严重急性呼吸冠状病毒 2 的抗原检测有时会比其指定的读取时间更早地显示阳性线，尽管尚不清楚在更早的时间获得结果的含义。
方法
我们前瞻性地收集了已经通过逆转录聚合酶链反应检测出 SARS-CoV-2 阳性的患者的额外鼻咽样本。使用拭子进行抗原检测，QuickNavi™-COVID19 Ag，并测量获得阳性结果的时间。
结果
在 96 例分析病例中的 84 例（87.5%）中，QuickNavi™-COVID19 Ag 的结果为阳性。中位阳性结果时间为 15.0 秒（四分位距：12.0-33.3，范围 11-736），较高的循环阈值样本中阳性结果时间延长（p<0.001）。85.7%的病例在 1 分钟内出现阳性线，96.4%的病例在 5 分钟内出现阳性线。
结论
QuickNavi™-COVID19 Ag 立即在大多数情况下显示出阳性结果，阳性反应的时间可能表明了病毒载量。
Zotero 插件