Hoa Le Thi Viet, Dang Hai Pham
Intensive Care Unit, Tam Anh General Hospital, Hanoi, Vietnam.
108 Institute of Clinical Medical and Pharmaceutical Sciences, Hanoi, Vietnam.
Am J Case Rep. 2021 Nov 20;22:e933992. doi: 10.12659/AJCR.933992.
BACKGROUND Elizabethkingia meningoseptica is an emerging pathogen in hospital environments. Immunocompromised individuals have a high risk of infections caused by E. meningoseptica, especially after transplantation. E. meningoseptica is associated with prolonged hospital stays and high mortality. In addition, E. meningoseptica is commonly resistant to many antibiotics used for gram-negative bacterial infections. We introduce the first case of E. meningoseptica bacteremia in a recipient of a liver transplant in Vietnam. CASE REPORT A 55-year-old woman with end-stage liver disease due to biliary cirrhosis underwent living donor liver transplantation at the 108 Military Central Hospital. On day 3 after transplantation, the patient had an acute cellular rejection, and corticosteroid pulse therapy was used. On day 7 after transplantation, the patient had a fever and an increased white blood cell count and C-reactive protein level. Blood cultures were positive for E. meningoseptica. Intravenous levofloxacin was administered for 10 days. The patient showed an excellent treatment response to the antibiotic therapy and was discharged. CONCLUSIONS E. meningoseptica, a multidrug-resistant gram-negative bacteria, can be considered an emerging pathogen in the hospital environment, especially in patients receiving organ transplants. Early recognition helps physicians to improve patient outcomes.
脑膜败血伊丽莎白金菌是医院环境中一种新出现的病原体。免疫功能低下的个体,尤其是在移植后,感染脑膜败血伊丽莎白金菌的风险很高。脑膜败血伊丽莎白金菌与住院时间延长和高死亡率相关。此外,脑膜败血伊丽莎白金菌通常对许多用于革兰氏阴性菌感染的抗生素耐药。我们介绍越南首例肝移植受者发生脑膜败血伊丽莎白金菌血症的病例。病例报告:一名55岁因胆汁性肝硬化导致终末期肝病的女性在第108军事中心医院接受了活体供肝移植。移植后第3天,患者发生急性细胞排斥反应,采用了糖皮质激素冲击治疗。移植后第7天,患者出现发热,白细胞计数和C反应蛋白水平升高。血培养显示脑膜败血伊丽莎白金菌阳性。给予静脉注射左氧氟沙星10天。患者对抗生素治疗显示出良好的治疗反应并出院。结论:脑膜败血伊丽莎白金菌是一种多重耐药革兰氏阴性菌,可被视为医院环境中的一种新出现病原体,尤其是在接受器官移植的患者中。早期识别有助于医生改善患者预后。