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全球金黄杆菌属菌株的抗菌药敏性及流行病学:哨兵抗菌监测计划(1997 - 2001年)报告

Antimicrobial susceptibility and epidemiology of a worldwide collection of Chryseobacterium spp: report from the SENTRY Antimicrobial Surveillance Program (1997-2001).

作者信息

Kirby Jeffrey T, Sader Helio S, Walsh Timothy R, Jones Ronald N

机构信息

The Jones Group/JMI Laboratories, North Liberty, Iowa, USA.

出版信息

J Clin Microbiol. 2004 Jan;42(1):445-8. doi: 10.1128/JCM.42.1.445-448.2004.

Abstract

Limited data are available on Chryseobacterium spp. leading to an evaluation of the patient demographics and susceptibility patterns for Chryseobacterium spp. collected in the first 5 years of the SENTRY Antimicrobial Surveillance Program (1997 to 2001). Fifty isolates (24 Chryseobacterium meningosepticum, 20 Chryseobacterium indologenes, two Chryseobacterium gleum, and 4 Chryseobacterium spp. isolates) were collected. The highest Chryseobacterium prevalence was detected among the elderly. The most active antimicrobials were the newer quinolones (garenoxacin, gatifloxacin, and levofloxacin, each with a MIC at which 90 percent of the isolates are inhibited [MIC(90)] of 1 micro g/ml and 98.0% susceptibility) followed by rifampin (MIC(90), 2 microg/ml and 85.7% susceptibility). Trimethoprim-sulfamethoxazole, ciprofloxacin, and piperacillin-tazobactam also showed reasonable activity; vancomycin showed poor potency.

摘要

关于金黄杆菌属的数据有限,这促使我们对哨兵抗菌监测计划(1997年至2001年)头5年收集的金黄杆菌属患者人口统计学特征和药敏模式进行评估。共收集了50株菌株(24株脑膜炎败血金黄杆菌、20株产吲哚金黄杆菌、2株黏金黄杆菌和4株未明确的金黄杆菌属菌株)。在老年人中检测到金黄杆菌属的患病率最高。活性最强的抗菌药物是新型喹诺酮类(加替沙星、加替沙星和左氧氟沙星,其对90%分离株的最低抑菌浓度[MIC(90)]均为1μg/ml,药敏率为98.0%),其次是利福平(MIC(90)为2μg/ml,药敏率为85.7%)。甲氧苄啶-磺胺甲恶唑、环丙沙星和哌拉西林-他唑巴坦也显示出合理的活性;万古霉素活性较差。

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