Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA.
Curr Gastroenterol Rep. 2021 Nov 19;23(12):27. doi: 10.1007/s11894-021-00823-4.
The purpose of this article is to review the cornerstone and most recent literature regarding laryngopharynoesophageal reflux (LPR) including epidemiological characteristics, pathophysiology, symptoms, diagnosis, and management. The role of pepsin in the pathophysiology of LPR is highlighted in addition to new diagnostic modalities and pharmacologic therapies that target pepsin.
本文旨在回顾有关喉咽食管反流（LPR）的基石和最新文献，包括流行病学特征、病理生理学、症状、诊断和治疗。本文强调了胃蛋白酶在 LPR 病理生理学中的作用，以及针对胃蛋白酶的新诊断方法和药物治疗。
