James J, Ferguson M M, Forsyth A, Tulloch N, Lamey P J
Department of Oral Surgery, Glasgow Dental Hospital and School.
Br J Oral Maxillofac Surg. 1987 Dec;25(6):474-80. doi: 10.1016/0266-4356(87)90139-2.
Lichen planus is a common disorder of unknown aetiology. It has been proposed that in some cases it represents a form of allergic reaction to the metals contained in dental amalgam, particularly mercury. Twenty-nine consecutive dentate patients who had lichen planus of the oral mucosa were patch-tested to the range of metals contained in dental amalgam. Ten out of 29 (34%) showed an allergic reaction to mercury and all of these patients had amalgams greater than 5 years old. The amalgams were poorly contoured and had corroded, resulting in continued release of mercury ions. Six patients had their amalgams replaced with composite or glass ionomer materials resulting in resolution of ulcerated lesions. In a follow-up of 3-24 months, one patient had a recurrence of ulcerated areas and another, despite resolution of the oral lesions had persistent discomfort.
扁平苔藓是一种病因不明的常见病症。有人提出，在某些情况下，它代表了对牙科汞合金中所含金属，尤其是汞的一种过敏反应形式。对连续29例患有口腔黏膜扁平苔藓的有牙患者进行了对牙科汞合金所含一系列金属的斑贴试验。29例中有10例（34%）对汞有过敏反应，所有这些患者的汞合金使用年限都超过了5年。这些汞合金外形不佳且已腐蚀，导致汞离子持续释放。6例患者的汞合金被复合树脂或玻璃离子材料替换，溃疡病变得以消退。在3至24个月的随访中，1例患者溃疡区域复发，另1例尽管口腔病变消退，但仍持续感到不适。
