Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China.
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China.
Adv Healthc Mater. 2022 Feb;11(3):e2101578. doi: 10.1002/adhm.202101578. Epub 2022 Jan 7.
The rapid postoperative recurrence and short survival time of glioblastoma (GBM) patients necessitate immediate and effective postoperative treatment. Herein, an immediate and mild postoperative local treatment strategy is developed that regulates the postoperative microenvironment and delays GBM recurrence. Briefly, an injectable hydrogel system (imGEL) loaded with Zn(II) -AMD3100 (AMD-Zn) and CpG oligonucleotide nanoparticles (CpG NPs) is injected into the operation cavity, with long-term function to block the recruitment of microglia/ macrophages and activate cytotoxic T cells. The finding indicated that the imGEL can regulate the immune microenvironment, inhibit GBM recurrence, and gain valuable time for subsequent adjuvant clinical chemotherapy.
胶质母细胞瘤（GBM）患者术后快速复发和生存时间短，需要立即进行有效的术后治疗。在此，开发了一种即时且温和的术后局部治疗策略，可调节术后微环境并延缓 GBM 复发。简而言之，将负载 Zn(II)-AMD3100（AMD-Zn）和 CpG 寡核苷酸纳米粒（CpG NPs）的可注射水凝胶系统（imGEL）注入手术腔，具有长期阻断小胶质细胞/巨噬细胞募集和激活细胞毒性 T 细胞的功能。研究结果表明，imGEL 可调节免疫微环境，抑制 GBM 复发，并为后续辅助临床化疗争取宝贵时间。
