Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea.
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
ACS Nano. 2023 Mar 28;17(6):5435-5447. doi: 10.1021/acsnano.2c10094. Epub 2023 Mar 16.
Postsurgical treatment of glioblastoma multiforme (GBM) by systemic chemotherapy and radiotherapy is often inefficient. Tumor cells infiltrating deeply into the brain parenchyma are significant obstacles to the eradication of GBM. Here, we present a potential solution to this challenge by introducing an injectable thermoresponsive hydrogel nanocomposite. As a liquid solution that contains drug-loaded micelles and water-dispersible ferrimagnetic iron oxide nanocubes (wFIONs), the hydrogel nanocomposite is injected into the resected tumor site after surgery. It promptly gelates at body temperature to serve as a soft, deep intracortical drug reservoir. The drug-loaded micelles target residual GBM cells and deliver drugs with a minimum premature release. Alternating magnetic fields accelerate diffusion through heat generation from wFIONs, enabling penetrative drug delivery. Significantly suppressed tumor growth and improved survival rates are demonstrated in an orthotopic mouse GBM model. Our system proves the potential of the hydrogel nanocomposite platform for postsurgical GBM treatment.
胶质母细胞瘤（GBM）的术后治疗通常采用全身化疗和放疗，但效果往往不尽人意。浸润到脑实质深处的肿瘤细胞是彻底清除 GBM 的重大障碍。在这里，我们通过引入一种可注射的温敏水凝胶纳米复合材料来解决这一挑战。这种水凝胶纳米复合材料是一种液体溶液，包含载药胶束和水分散性铁磁性氧化铁纳米立方（wFIONs），手术后将其注射到切除的肿瘤部位。它会在体温下迅速胶凝，形成一个柔软的、深层的皮质内药物储库。载药胶束靶向残留的 GBM 细胞，并以最小的早期释放来输送药物。交变磁场通过 wFIONs 产生的热量加速扩散，实现渗透性药物递送。在原位小鼠 GBM 模型中，显著抑制了肿瘤生长并提高了存活率。我们的系统证明了水凝胶纳米复合材料平台在 GBM 术后治疗中的潜力。
