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增殖增加与脑膜瘤的中枢神经系统侵犯有关。

Increased proliferation is associated with CNS invasion in meningiomas.

机构信息

Department of Neurosurgery, University Hospital Tübingen, Eberhard-Karls-University Tübingen, Tübingen, Germany.

Center for CNS Tumors, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital Tübingen, Eberhard-Karls-University Tübingen, Tübingen, Germany.

出版信息

J Neurooncol. 2021 Dec;155(3):247-254. doi: 10.1007/s11060-021-03892-7. Epub 2021 Nov 20.

DOI:10.1007/s11060-021-03892-7
PMID:34800210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8651603/
Abstract

INTRODUCTION

Meningiomas are the most common benign intracranial neoplasms. CNS invasion in meningiomas has been integrated into the 2016 WHO classification of CNS tumors as a stand-alone criterion for atypia. Since then, its prognostic impact has been debated based on contradictory results from retrospective analyses. The aim of the study was to elucidate whether histopathological evidence of CNS invasion is associated with increased proliferative potential.

METHODS

We have conducted a quantified measurement of the proliferation marker Ki67 and analyzed its association with CNS invasion determined by histology together with other established prognostic markers of progression. Routine, immunohistochemical staining for Ki67 were digitalized and automatic quantification was done using Image J software.

RESULTS

Overall, 1718 meningiomas were assessed. Histopathological CNS invasion was seen in 108 cases (6.7%). Uni- and multivariate analysis revealed a significantly higher Ki67 proliferation rate in meningiomas with CNS invasion (p < 0.0001 and p = 0.0098, respectively).

CONCLUSIONS

Meningiomas with histopathological CNS invasion show a higher proliferative activity.

摘要

简介

脑膜瘤是最常见的颅内良性肿瘤。中枢神经系统（CNS）侵犯已被纳入 2016 年 CNS 肿瘤世界卫生组织分类，作为非典型性的独立标准。此后，基于回顾性分析的相互矛盾的结果，其预后影响一直存在争议。本研究旨在阐明组织学上的 CNS 侵犯证据是否与增殖潜能增加有关。

方法

我们对增殖标志物 Ki67 进行了定量测量，并分析了其与组织学确定的 CNS 侵犯之间的关系，以及其他已确立的进展预后标志物。使用 Image J 软件对 Ki67 的常规免疫组织化学染色进行了数字化，并进行了自动定量。

结果

共评估了 1718 例脑膜瘤。108 例（6.7%）有组织学上的 CNS 侵犯。单因素和多因素分析显示，有 CNS 侵犯的脑膜瘤 Ki67 增殖率显著更高（p<0.0001 和 p=0.0098）。

结论

组织学上有 CNS 侵犯的脑膜瘤具有更高的增殖活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d7/8651603/bba43d3a432d/11060_2021_3892_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d7/8651603/7f9b90977815/11060_2021_3892_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d7/8651603/a33d61345310/11060_2021_3892_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d7/8651603/bba43d3a432d/11060_2021_3892_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d7/8651603/7f9b90977815/11060_2021_3892_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d7/8651603/a33d61345310/11060_2021_3892_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d7/8651603/bba43d3a432d/11060_2021_3892_Fig3_HTML.jpg

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