Zehani Alia, Chelly Ines, Haouet Slim, Kchir Nidhameddine
Tunis Med. 2017 Jul;95(7):466-470.
Although generally considered benign, meningiomas can cause significant morbidity and mortality. Histologic grade is the most useful morphologic predictor of recurrence.
To compare Ki67 labeling index between meningioma grade I and meningioma grade II with brain invasion.
We analyzed 20 primary meningioma, 10 of which were grade I and 10 of which were grade II. Ki67 proliferative indices were determined in all cases.
The patient population consisted of 9 males and 11 females with mean age of 60 years. For meningioma grade I, the Ki67 labeling index varied between 1 and 15% with an average of 3.1%. A diagnosis of gradeII meningiomas was made solely on the basis of brain invasion. The immunohistochemical study noted that the Ki67 index varied between 1 and 20% with an average of 6,8%.
The Ki67 labeling index shows a significant increase from grade I to grade II. It may provide useful prognostic information.
尽管脑膜瘤通常被认为是良性的，但它可导致严重的发病率和死亡率。组织学分级是复发最有用的形态学预测指标。
比较伴有脑侵袭的I级脑膜瘤和II级脑膜瘤之间的Ki67标记指数。
我们分析了20例原发性脑膜瘤，其中10例为I级，10例为II级。测定所有病例的Ki67增殖指数。
患者群体包括9名男性和11名女性，平均年龄60岁。对于I级脑膜瘤，Ki67标记指数在1%至15%之间变化，平均为3.1%。II级脑膜瘤的诊断仅基于脑侵袭。免疫组化研究表明，Ki67指数在1%至20%之间变化，平均为6.8%。
Ki67标记指数从I级到II级有显著增加。它可能提供有用的预后信息。
