Tian Tian, Cai Yu, Li Mei, Fang Yuan, Pan Yingzi
Department of Ophthalmology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, China.
Ophthalmol Ther. 2022 Feb;11(1):239-248. doi: 10.1007/s40123-021-00423-5. Epub 2021 Nov 20.
To evaluate the correlation between macular integrity assessment (MAIA) and standard automated perimetry (SAP) in detecting macular function damage in glaucoma and to explore the relationship between macular structure and functional damage by using spectral domain optical coherence tomography (SD-OCT).
This was a cross-sectional study. Seventy patients with glaucoma, with hemifield defects verified by Humphrey 24-2 examination, and 60 normal subjects underwent Humphrey 10-2 and MAIA expert 10-2 examinations. Patients with glaucoma with normal hemifields, as detected by SAP, were divided into a normal hemifield group and a visual field (VF) defect group. The difference in the retina and ganglion cell complex (GCC) thicknesses was analyzed between the abnormal and normal hemifields.
Among the 70 glaucoma eyes, the results of MAIA and SAP were consistent for 66 (66/70, 94.3%). The others showed SAP hemifield defects, while MAIA was normal (4/70, 5.7%). There was a good correlation of the mean sensitivity between MAIA and SAP (P < 0.001). There also was a good correlation between the mean threshold of MAIA and the mean deviation (MD) of SAP (P = 0.008, r = 0.507). Among the patients with glaucoma with a normal hemifield, MAIA showed abnormal results in 50 eyes (50/66, 75.8%), which was consistent with the changes in the inner retina and GCC thicknesses. Meanwhile, MAIA showed normal results; there were no significant differences between patients with glaucoma and the normal group in the thicknesses of the inner retina and GCC.
MAIA and SAP have good consistency in detecting macular dysfunction. MAIA can also identify abnormal VFs in the macular regions that may not be detected by SAP, which is consistent with the changes in the GCC thicknesses, suggesting that there may be central VF damage in patients with glaucoma that has not been previously identified.
评估黄斑完整性评估（MAIA）与标准自动视野计（SAP）在检测青光眼黄斑功能损害方面的相关性，并利用光谱域光学相干断层扫描（SD-OCT）探讨黄斑结构与功能损害之间的关系。
这是一项横断面研究。70例经Humphrey 24-2检查证实有半视野缺损的青光眼患者和60例正常受试者接受了Humphrey 10-2和MAIA专家10-2检查。经SAP检测，视野正常的青光眼患者被分为正常半视野组和视野（VF）缺损组。分析异常和正常半视野之间视网膜和神经节细胞复合体（GCC）厚度的差异。
在70只青光眼眼中，MAIA和SAP结果一致的有66只（66/70，94.3%）。其他显示SAP半视野缺损，而MAIA正常（4/70，5.7%）。MAIA与SAP之间的平均敏感度有良好相关性（P < 0.001）。MAIA的平均阈值与SAP的平均偏差（MD）之间也有良好相关性（P = 0.008，r = 0.507）。在视野正常的青光眼患者中，MAIA在50只眼中显示异常结果（50/66，75.8%），这与视网膜内层和GCC厚度的变化一致。同时，MAIA显示正常结果；青光眼患者与正常组在内层视网膜和GCC厚度上无显著差异。
MAIA和SAP在检测黄斑功能障碍方面具有良好的一致性。MAIA还可以识别SAP可能未检测到的黄斑区域异常视野，这与GCC厚度的变化一致，表明青光眼患者可能存在先前未被识别的中央视野损害。
