Glaucoma Research Facility and Clinical Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Vitreoretinal Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Indian J Ophthalmol. 2021 Apr;69(4):876-881. doi: 10.4103/ijo.IJO_1199_20.
To evaluate the central visual field by microperimetry (MP), in early glaucoma.
Consecutive perimetrically experienced patients with a single nasal step or arcuate scotoma and 14 control eyes underwent MP. Retinal sensitivity on MP was mapped for frequency and depth of loss in the central 10° around fixation.
Twenty-one eyes had a single nasal step and 19 eyes with single arcuate scotoma on standard automated perimetry (SAP), with central 10° being normal on 30-2 and 10-2 perimetry. The average mean sensitivity on MP, in glaucomatous and control eyes was 11.8 ± 3.9 dB and 16.6 ± 1.2 dB, respectively, P = 0.0004. The average mean defect on MP-1, in glaucomatous and control eyes was -6.5 ± 2.0 dB and -3.0 ± 1.2 Db, respectively, P = 0.05. The corresponding retinal hemisphere showed significant defects in MP. In eyes with single nasal steps, an absolute scotoma was seen in 14-28% of eyes 8-10° off fixation, moderate to mild defects were seen in 10-52% eyes, and 10% eyes showed involvement up to 4° from the fixation. Eyes with arcuate scotoma had an absolute scotoma on MP in 95% of eyes, 6-10° from fixation, with extension up to 2° from fixation in 21%. In glaucomatous eyes, the normal hemisphere on SAP showed a mild defect on MP in 43%. Control eyes did not show any defect in SAP or MP.
A significant loss of central retinal sensitivity is recorded on MP in early glaucomatous neuropathy as compared to SAP. Paramacular absolute defects were seen at 6-10° from fixation.
通过微视野计（MP）评估早期青光眼的中央视野。
对连续的、具有单侧鼻侧阶梯或弓形暗点的经验丰富的视野检查患者以及 14 只对照眼进行 MP 检查。在中央 10°范围内，以注视点为中心，对 MP 上的视网膜敏感性进行频率和深度损失映射。
21 只眼在标准自动视野计（SAP）上有单侧鼻侧阶梯，19 只眼有单侧弓形暗点，30-2 和 10-2 视野检查的中央 10°正常。青光眼和对照组眼在 MP 上的平均平均敏感度分别为 11.8±3.9dB 和 16.6±1.2dB，P=0.0004。青光眼和对照组眼在 MP-1 上的平均平均缺损分别为-6.5±2.0dB 和-3.0±1.2dB，P=0.05。相应的视网膜半球在 MP 上显示出明显的缺陷。在单侧鼻侧阶梯的眼中，在注视点 8-10°之外的 14-28%的眼中可见绝对暗点，10-52%的眼中可见中度至轻度缺陷，10%的眼中可见从注视点延伸至 4°的病变。具有弓形暗点的眼中，在注视点 6-10°之外的 95%的眼中在 MP 上有绝对暗点，在 21%的眼中从注视点延伸至 2°之外。在青光眼眼中，SAP 上正常的半球在 MP 上有 43%显示轻度缺陷。对照组眼在 SAP 或 MP 上均未显示任何缺陷。
与 SAP 相比，早期青光眼神经病变患者在 MP 上记录到中央视网膜敏感性的显著丧失。在注视点 6-10°之外可以看到旁中心绝对缺损。
