Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri, USA.
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Diagn Cytopathol. 2022 Apr;50(4):164-171. doi: 10.1002/dc.24902. Epub 2021 Nov 20.
The term "atypical" has had a long history of usage in cytology but has had variable definitions and usage. Most commonly the term was used to indicate a degree of cytomorphologic abnormality greater than that clearly due to reactive or reparative changes but not associated with a high concern on the part of the cytopathologist that a malignancy is present. The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology provided a foundation for using the category "Atypical" along with the category "Suspicious for Malignancy" to categorize the spectrum of morphologic changes ranging from those which are clearly benign to those that are clearly malignant. The two intermediate categories of "Atypical" and "Suspicious for Malignancy" have characteristic recommendations resulting in clinical utility for both categories.
The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology represents a useful system with defined intermediate categories of Atypical and Suspicious for Malignancy.
“非典型”一词在细胞学中有很长的使用历史，但定义和用法各不相同。最常见的是，该术语用于表示细胞形态异常的程度大于明显由反应性或修复性变化引起的程度，但与细胞病理学家对恶性肿瘤存在的高度关注无关。巴氏涂片细胞学协会报告呼吸系统细胞学系统为使用“非典型”类别以及“疑似恶性”类别提供了基础，用于对从明显良性到明显恶性的形态变化范围进行分类。“非典型”和“疑似恶性”这两个中间类别具有特征性建议，对这两个类别都具有临床实用性。
巴氏涂片细胞学协会报告呼吸系统细胞学系统是一个有用的系统，具有明确的中间类别“非典型”和“疑似恶性”。
