Reference Center for Rare Pulmonary Diseases, Pulmonary Medicine and Intensive Care Unit Department, Dijon University Hospital, BP 77908, 21079, Dijon, France.
CHU de Dijon - Service de Biostatistique et d'Informatique Médicale, BP 77908, 21079, Dijon CEDEX, France.
Respir Res. 2021 Nov 20;22(1):298. doi: 10.1186/s12931-021-01887-6.
This study assessed the impact of the COVID-19 epidemic on overall hospitalizations for pulmonary embolism (PE) in France in comparison with previous years, and by COVID-19 and non-COVID-19 status.
Hospitalization data (2017-2020) were extracted from the French National Discharge database (all public and private hospitals). We included all patients older than 18 years hospitalized during the 3 years and extracted PE status and COVID-19 status (from March 2020). Age, sex and risk factors for PE (such as obesity, cancer) were identified. We also extracted transfer to an intensive care unit (ICU) and hospital death. The number of PE and the frequency of death in patients in 2019 and 2020 were described by month and by COVID-19 status. Logistic regressions were performed to identify the role of COVID-19 among other risk factors for PE in hospitalized patients.
The overall number of patients hospitalized with PE increased by about 16% in 2020 compared with 2019, and mortality also increased to 10.3% (+ 1.2%). These increases were mostly linked to COVID-19 waves, which were associated with PE hospitalization in COVID-19 patients (PE frequency was 3.7%; 2.8% in non-ICU and 8.8% in ICU). The final PE odds ratio for COVID-19 hospitalized patients was 4 compared with other hospitalized patients in 2020. The analyses of PE in non-COVID-19 patients showed a 2.7% increase in 2020 compared with the previous three years.
In 2020, the overall number of patients hospitalized with PE in France increased compared to the previous three years despite a considerable decrease in scheduled hospitalizations. Nevertheless, proactive public policy focused on the prevention of PE in all patients should be encouraged.
本研究评估了 COVID-19 大流行对法国肺栓塞（PE）总住院人数的影响，并按 COVID-19 和非 COVID-19 状态进行了比较。
从法国国家出院数据库（所有公立和私立医院）中提取了住院数据（2017-2020 年）。我们纳入了所有年龄大于 18 岁的在三年内住院的患者，并提取了 PE 状态和 COVID-19 状态（自 2020 年 3 月起）。确定了年龄、性别和 PE 的危险因素（如肥胖、癌症）。我们还提取了转入重症监护病房（ICU）和院内死亡的情况。描述了 2019 年和 2020 年每月按 COVID-19 状态划分的 PE 患者数量和死亡频率。进行了 logistic 回归分析，以确定 COVID-19 在住院患者的 PE 其他危险因素中的作用。
与 2019 年相比，2020 年因 PE 住院的患者总数增加了约 16%，死亡率也上升至 10.3%（+1.2%）。这些增加主要与 COVID-19 浪潮有关，这些浪潮与 COVID-19 患者的 PE 住院有关（PE 发生率为 3.7%；非 ICU 为 2.8%，ICU 为 8.8%）。与 2020 年其他住院患者相比，COVID-19 住院患者的最终 PE 比值比为 4。对非 COVID-19 患者的 PE 分析显示，2020 年与前三年相比增加了 2.7%。
尽管计划住院治疗的数量大幅减少，但与前三年相比，2020 年法国因 PE 住院的患者总数增加。然而，应鼓励采取积极的公共政策，关注所有患者的 PE 预防。
