雄激素治疗恶病质的疗效。

Therapeutic effects of androgens for cachexia.

机构信息

Department of Medical Biotechnology and Translational Medicine, University of Milan, 20100, Milan, Italy; Department of Endocrine and Metabolic Medicine, IRCCS Istituto Auxologico Italiano, 20100, Milan, Italy; Department of Endocrinology, Diabetes & Metabolism, Newcastle-upon-Tyne Hospitals, NE1 4LP, UK.

Department of Endocrinology, Diabetes & Metabolism, Newcastle-upon-Tyne Hospitals, NE1 4LP, UK; Translational & Clinical Research Institute, University of Newcastle-upon-Tyne, NE1 3BZ, UK.

出版信息

Best Pract Res Clin Endocrinol Metab. 2022 Sep;36(5):101598. doi: 10.1016/j.beem.2021.101598. Epub 2021 Nov 10.

DOI:10.1016/j.beem.2021.101598

PMID:34801415

Abstract

Cachexia is a complex wasting syndrome, accompanying a variety of end-stage chronic diseases, such as cancer, heart failure and human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS). It significantly affects patients' quality of life and survival. Multiple therapeutic approaches have been studied over time. However, despite promising results, no drug has been approved to date. In this review, we examine and discuss the available data on the therapeutic effects of androgens and selective androgen receptor modulators (SARMs) for cachexia.

摘要

恶病质是一种复杂的消耗性综合征，伴随着多种终末期慢性疾病，如癌症、心力衰竭和人类免疫缺陷病毒（HIV）感染/获得性免疫缺陷综合征（AIDS）。它严重影响患者的生活质量和生存。随着时间的推移，已经研究了多种治疗方法。然而，尽管有希望的结果，迄今为止没有一种药物获得批准。在这篇综述中，我们检查并讨论了雄激素和选择性雄激素受体调节剂（SARMs）治疗恶病质的疗效的现有数据。