Dai Yunlang, Zhou Jing, Niu Lijuan, Hu Junting, Han Junxia
Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Department of Endocrinology, the First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Clin Chim Acta. 2022 Jan 1;524:187-191. doi: 10.1016/j.cca.2021.11.015. Epub 2021 Nov 18.
Accumulated evidence have revealed profound associations between C1q/TNF-related proteins (CTRPs) and coronary artery disease (CAD); yet, the relationship of CTRP4 to CAD has not been investigated. We examined the role of CTRP4 in CAD, and especially in acute coronary syndrome (ACS).
A total of 138 patients referred for coronary angiography were included in this study and were classified into 3 groups (ACS, CAD and control group). Comparisons regarding clinical data and CTRP4 concentration were performed among 3 groups. Weighted least-squares regression analysis was used to identify the independent predicting factors for CTRP4.
Compared with either CAD (median 7.19 vs. 9.43, P < 0.05) or control group (median 7.22 vs. 9.43, P < 0.01), ACS group showed higher CTRP4 concentration. In addition, trend χ test revealed the presence of ACS increased with increased CTRP4 concentration (P = 0.010). Finally, in the weighted least-squares regression analysis, ACS was the only independent variable influencing CTRP4 concentration (β- coefficient = 3.082, P = 0.004), even after adjusting for high-sensitivity C reactive protein (β- coefficient = 3.050, P = 0.007).
CTRP4 was associated with ACS; moreover, ACS was the independent factor in predicting CTRP4 concentration. The potentially important implications of CTRP4 in ACS may offer a novel insight into understanding the link between inflammation and ACS.
越来越多的证据表明补体C1q/肿瘤坏死因子相关蛋白（CTRPs）与冠状动脉疾病（CAD）之间存在密切关联；然而，CTRP4与CAD的关系尚未得到研究。我们研究了CTRP4在CAD，尤其是急性冠状动脉综合征（ACS）中的作用。
本研究共纳入138例接受冠状动脉造影的患者，并将其分为3组（ACS组、CAD组和对照组）。对3组患者的临床资料和CTRP4浓度进行比较。采用加权最小二乘法回归分析确定CTRP4的独立预测因素。
与CAD组（中位数7.19对9.43，P<0.05）或对照组（中位数7.22对9.43，P<0.01）相比，ACS组的CTRP4浓度更高。此外，趋势χ检验显示，随着CTRP4浓度升高，ACS的发生率增加（P=0.010）。最后，在加权最小二乘法回归分析中，即使校正了高敏C反应蛋白后，ACS仍是影响CTRP4浓度的唯一独立变量（β系数=3.082，P=0.004）（β系数=3.050，P=0.007）。
CTRP4与ACS相关；此外，ACS是预测CTRP4浓度的独立因素。CTRP4在ACS中的潜在重要意义可能为理解炎症与ACS之间的联系提供新的视角。
