Liu Zheng, Lu Jinhua, Zhang Daiyi, Niu Lijuan, Shi Bimin
Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Geriatrics, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ther Adv Endocrinol Metab. 2021 Nov 30;12:20420188211059884. doi: 10.1177/20420188211059884. eCollection 2021.
To detect serum C1Q/TNF-related protein 4 (CTRP4) concentrations in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and evaluate the correlation between CTRP4 and other variables in T2DM.
Sixty-five patients with newly diagnosed T2DM and eighty-nine healthy volunteers were enrolled in this study. Anthropometric and biochemical data of the study participants was collected, and serum CTRP4 concentrations were detected by enzyme-linked immunosorbent assay (ELISA) kit. The correlation between serum CTRP4 and other indexes was analyzed by Spearman correlation analysis. Trend χ test and binary multivariate stepwise logistic regression were performed to assess the correlation between CTRP4 and the risk of T2DM.
Serum CTRP4 concentrations in the T2DM group were significantly lower than those in the control group ( < .01). Spearman correlation analysis showed that CTRP4 concentrations were negatively correlated with BMI, hs-CRP, HOMA-IR, FBG and TG ( = - 0.430, - 0.453, - 0.371, - 0.361, - 0.506, < .05), and positively correlated with HDL-c ( = 0.303, < .05). Trend χ test indicated that with the increase of CTRP4 levels in the population, the risk of T2DM presented a general downward trend ( < .01). Binary multivariate stepwise logistic regression suggested that serum CTRP4 was an independent impact factor for T2DM and high serum CTRP4 levels were related to the decreased risk of T2DM (P < .05).
Serum CTRP4 concentrations decrease in patients with newly diagnosed T2DM. Serum CTRP4 levels are negatively associated with the risk of T2DM.
检测新诊断2型糖尿病（T2DM）患者血清C1Q/TNF相关蛋白4（CTRP4）浓度，并评估CTRP4与T2DM其他变量之间的相关性。
本研究纳入65例新诊断的T2DM患者和89名健康志愿者。收集研究参与者的人体测量和生化数据，采用酶联免疫吸附测定（ELISA）试剂盒检测血清CTRP4浓度。采用Spearman相关性分析血清CTRP4与其他指标之间的相关性。进行趋势χ检验和二元多因素逐步logistic回归，以评估CTRP4与T2DM风险之间的相关性。
T2DM组血清CTRP4浓度显著低于对照组（<0.01）。Spearman相关性分析显示，CTRP4浓度与BMI、hs-CRP、HOMA-IR、FBG和TG呈负相关（r=-0.430、-0.453、-0.371、-0.361、-0.506，P<0.05），与HDL-c呈正相关（r=0.303，P<0.05）。趋势χ检验表明，随着人群中CTRP4水平的升高，T2DM风险呈总体下降趋势（P<..01）。二元多因素逐步logistic回归表明，血清CTRP4是T2DM的独立影响因素，血清CTRP4水平升高与T2DM风险降低相关（P<0.05）。
新诊断的T2DM患者血清CTRP4浓度降低。血清CTRP4水平与T2DM风险呈负相关。
