药物相关问题对有子痫前期病史的女性住院时间的影响：一项多中心研究。
Influence of drug-related problems on length of hospital stay of women with a history of preeclampsia: A multicenter study.
机构信息
Laboratory of Teaching and Research in Social Pharmacy, Department of Pharmacy, Federal University of Sergipe, São Cristóvão, SE, Brazil. Address: Cidade Universitária "Prof. José Aloísio Campos", Jardim Rosa Elze, São Cristóvão CEP: 49100-000, Brazil.
Pharmacotherapy Research Group, Institute of Pharmaceutical Sciences, Federal University of Alagos, Maceió, AL, Brazil. Endereço: Campus A. C. Simões. Av. Lourival Melo Mota, se/n, Tabuleiro do Martins, Maceió, Alagoas. CEP: 57072-970.
出版信息
Pregnancy Hypertens. 2022 Mar;27:8-13. doi: 10.1016/j.preghy.2021.11.005. Epub 2021 Nov 10.
BACKGROUND
Approximately 5-7 % of pregnant women have hypertension during pregnancy, requiring antihypertensive drug treatment. There have been a lack of studies evaluating how drug-related problems (DRPs) affect morbidity or mortality in the postpartum period among women with a history of preeclampsia.
OBJECTIVE
To determine the influence of drug-related problems on length of hospital stay of postpartum women with a history of preeclampsia.
METHODS
This cross-sectional study included postpartum women diagnosed with preeclampsia, from June to November 2016, in two teaching maternity hospitals in Brazil. The outcomes assessed were, length of hospital stay of postpartum women. The DRPs were classified through the Pharmaceutical Care Network Europe Foundation (PCNE) v 8.01.
RESULTS
600 women were included, and 354 (59%) were exposed to at least one DRP. The most frequent DRPs were no administration of the prescribed medication, lack of prescription of a medication, although the indication was clear, and ineffectiveness (unknown reason). In patients exposed to DRP, the average length of hospital stay after labour was 5.4 (S.D. 3.6) days versus 4.4 (S.D. 3.3) days in patients non-exposed to DRP (p = 0.0001). The period (in days) to achieve blood pressure control after labour was 4.5 (S.D. 3.5) 3.5 (S.D. 3.2), respectively (p = 0.0001). There were no deaths during the study.
CONCLUSION AND RELEVANCE
Drug-related problems significantly increased the length of hospital stay in postpartum women with a history of preeclampsia.
背景
大约有 5-7%的孕妇在怀孕期间患有高血压，需要接受抗高血压药物治疗。目前缺乏研究评估药物相关问题 (DRP) 如何影响有先兆子痫病史的女性在产后期间的发病率或死亡率。
目的
确定药物相关问题对有先兆子痫病史的产后妇女住院时间的影响。
方法
这是一项横断面研究，纳入了 2016 年 6 月至 11 月期间在巴西的两家教学妇产医院诊断为先兆子痫的产后妇女。评估的结果是产后妇女的住院时间。药物相关问题通过欧洲药学保健网络基金会 (PCNE) v 8.01 进行分类。
结果
共纳入 600 名妇女，其中 354 名（59%）至少存在一种药物相关问题。最常见的药物相关问题是未给予规定的药物、尽管有明确的适应证但未开处方药物、以及药物无效（未知原因）。在存在药物相关问题的患者中，分娩后平均住院时间为 5.4（S.D. 3.6）天，而不存在药物相关问题的患者为 4.4（S.D. 3.3）天（p=0.0001）。分娩后达到血压控制的时间（天）分别为 4.5（S.D. 3.5）和 3.5（S.D. 3.2）（p=0.0001）。研究期间无死亡。
结论和相关性
药物相关问题显著增加了有先兆子痫病史的产后妇女的住院时间。
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