Larasati Niken, Satibi Satibi, Kristina Susi Ari, Lazuardi Lutfan
Doctoral Program in Pharmacy, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia.
Pharmacy Study Program, Faculty of Health, Jenderal Achmad Yani University, Yogyakarta, Indonesia.
Malays J Med Sci. 2024 Aug;31(4):162-173. doi: 10.21315/mjms2024.31.4.13. Epub 2024 Aug 27.
Drug-related problems (DRPs) are treatment-related occurrences that affect therapeutic efficacy. In a previous study, approximately 279 out of 330 (84.5%) patients with type 2 diabetes mellitus (T2DM) had experienced at least one DRP, including non-optimal drug effects ( = 240, 52.7%) and indications without medication ( 137, 30.1%). Patients who were hospitalised for 5-10 days had the highest number of DRPs. Therefore, this study investigates the association between DRPs and length of stay (LoS) in patients with T2DM.
A cross-sectional study was conducted from January 2020 to May 2023 at Rumah Sakit Akademik, Universitas Gadjah Mada, Yogyakarta, Indonesia. Clinical pharmacists reviewed electronic health data to examine DRPs. The Fisher's exact test evaluated the association between DRPs and LoS.
A total of 60.7% ( = 17) of the participants were females, with the majority falling into the age group ≥ 65 years old ( = 11, 29.7%). A significant portion experienced LoS > 7 days ( = 17, 60.7%). Antidiabetic monotherapy was predominant, and the categories of DRPs included adverse drug reaction ( 15, 40.5%), dosage too high ( = 6, 16.2%), wrong drug ( = 6, 16.2%), non-adherence ( = 4, 10.8%), need for additional therapy ( 4, 10.8%) and dosage too low ( 2, 5.4%). A significant association was observed between non-adherence and LoS ( 0.016). The possibility of experiencing LoS of 1-7 days increased by 3.43 times with improved non-adherence (OR = 3.43; 95% CI: 1.83, 6.39). In this context, non-adherence refers to DRPs associated with the non-compliance of patients with the prescribed treatment plan.
This study concludes that non-adherence was significantly associated with hospital LoS.
药物相关问题（DRPs）是影响治疗效果的与治疗相关的事件。在之前的一项研究中，330例2型糖尿病（T2DM）患者中约279例（84.5%）至少经历过一次DRP，包括药物效果不佳（=240，52.7%）和无药物治疗指征（137，30.1%）。住院5 - 10天的患者DRP数量最多。因此，本研究调查T2DM患者中DRPs与住院时间（LoS）之间的关联。
2020年1月至2023年5月在印度尼西亚日惹加查马达大学学术医院进行了一项横断面研究。临床药师审查电子健康数据以检查DRPs。Fisher精确检验评估DRPs与LoS之间的关联。
共有60.7%（=17）的参与者为女性，大多数属于≥65岁年龄组（=11，29.7%）。很大一部分患者住院时间>7天（=17，60.7%）。抗糖尿病单药治疗为主，DRP类别包括药物不良反应（=15，40.5%）、剂量过高（=6，16.2%）、药物错误（=6，16.2%）、不依从（=4，10.8%）、需要额外治疗（4，10.8%）和剂量过低（2，5.4%）。观察到不依从与LoS之间存在显著关联（0.016）。不依从改善后，住院1 - 7天的可能性增加3.43倍（OR = 3.43；95% CI：1.83，6.39）。在此背景下，不依从是指与患者不遵守规定治疗方案相关的DRPs。
本研究得出结论，不依从与住院时间显著相关。
